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FLASH GENE

Symbol

KCNJ15

contributors: mct/npt - updated : 10-09-2009

HGNC name	potassium inwardly-rectifying channel, subfamily J, member 15
HGNC id	6261

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	21q22.13      Physical location : 39.628.663 - 39.673.744
Synonym name	ATP-sensitive inward rectifier potassium channel 15
	inward rectifier K+ channel KIR4.2
Synonym symbol(s)	KIR4.2, IRKK, KIR1.3, KIR4.2, MGC13584, KCNJ14

DNA

TYPE	functioning gene
STRUCTURE	45.08 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - PRED67 - SETD4 - CBR1 - CBR3 - DOPEY2 - MORC3 - CHAF1B - CLDN14 - SIM2 - HLCS HLCS - PIGP - TTC3 - DSCR3 - DYRK1A - KCNJ6 - PRED69 - KCNJ15 - ERG - ETS2 - PSMG1 - BRWD1 - HMG14P - SH3BGR - B3GALT5 - PCP4 - DSCAM - BACE2 - FAM3B - MX2 ,MX1 - TMPRSS2 - qter
Authors	Pletcher(01)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002243 4 - 2867 NP_002234 - 375 - Sindic (2009) NM_170736 3 - 2919 NP_733932 - 375 - Sindic (2009) NM_170737 3 - 2732 NP_733933 - 375 - Sindic (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly Nervous brain         Urinary kidney renal medulla     highly

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two membrane-spanning domains
	an amphipatic region pore, including the P domain with the K+ channel signature
	an ATP-binding regulatory domain
	a C-terminal PDZ domain (Sindic 2009)

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY	inward rectifier-type potassium channel family
	subfamily J

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION

having an extreme pH sensitivity which has implications for the role of this subunit as a homotetrameric channel (Pessia 2001)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts selectively with MPDZ to affect its cell surface expression (Sindic 2009)
	interacts directly with KCNJ10 and CASR and can decrease their currents, which in turn could reduce recycling of K(+) for the basolateral Na(+)-K(+)-ATPase and thereby contribute to inhibition of Na(+) reabsorption (Huang 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to type 2 diabetes (T2DM)affecting lean individuals

Variant & Polymorphism SNP	SNP, rs3746876, in exon 4 (C566T), with T allele frequency among control subjects of 3.1p100, showed a significant association with T2DM affecting lean individuals (Okamoto 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS