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FLASH GENE
Symbol ERG contributors: mct/npt/pgu - updated : 09-04-2014
HGNC name v-ets erythroblastosis virus E26 oncogene homolog (avian)
HGNC id 3446
Location 21q22.2      Physical location : 39.751.951 - 40.033.704
Genatlas name Ets-Related Gene
Synonym name
  • v-ets erythroblastosis virus E26 oncogene like (avian)
  • v-ets avian erythroblastosis virus E26 oncogene related
  • transcriptional regulator ERG (transforming protein ERG)
  • TMPRSS2-ERG prostate cancer specific
  • Synonym symbol(s) p55, erg-3
    DNA
    TYPE functioning gene
    STRUCTURE 294.52 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure several potential transcription factor binding sites but there were no Bright or Cart-1 sites
    MAPPING cloned Y linked N status confirmed
    Map see AML1 , ETS2
    Physical map
    ZCWCC3 21q22.13 zinc finger, CW-type with coiled-coil domain 3 CHAF1B 21q22.2 chromatin assembly factor 1, subunit B (p60) CLDN14 21q22.3 claudin 14 PSMD15 21q22.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 15 LOC388823 21 LOC388823 SIM2 21q22.2 single-minded homolog 2 (Drosophila) HLCS 21q22.2 holocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) MRPL20P1 21q22.2 holocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) DSCR6 21q22.2 Down syndrome critical region gene 6 DSCR5 21q22.2 Down syndrome critical region gene 5 TTC3 21q22.2 tetratricopeptide repeat domain 3 DSCR9 21q22.13 Down syndrome critical region gene 9 DSCR3 21q22.3 Down syndrome critical region gene 3 DYRK1A 21q22.2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A KCNJ6 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 6 DSCR4 21q22.2 Down syndrome critical region gene 4 DSCR8 21q22.2 Down syndrome critical region gene 8 DSCR10 21q22.2 Down syndrome critical region gene 10 KCNJ15 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 15 LOC388824 21 LOC388824 ERG 21q22.2 v-ets erythroblastosis virus E26 oncogene like (avian) ETS2 21q22.3 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) LOC391282 21 similar to 60S ribosomal protein L23a PCBP2P1 21q22.3 poly(rC) binding protein 2, pseudogene 1 DSCR2 21q22.3 Down syndrome critical region gene 2 C21orf107 21 chromosome 21 open reading frame 107 C21orf87 21q22.1 chromosome 21 open reading frame 87 HMGN1 21q22.3 high-mobility group nucleosome binding domain 1 WRB 21q22.3 tryptophan rich basic protein MGC33295 21q22.2 hypothetical protein MGC33295 SH3BGR 21q22.3 SH3 domain binding glutamic acid-rich protein B3GALT5 21q22.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 LOC388825 21 LOC388825 LOC150084 21q22.2 hypothetical protein LOC150084 PCP4 21q22.2-q22.3 Purkinje cell protein 4 DSCAM 21q22.2-q22.3 Down syndrome cell adhesion molecule
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4945 - 479 - 2009 19156837
    11 - 5042 - 462 - 2009 19156837
    12 - 5114 54.5 486 - 2009 19156837
    9 - 4727 44 387 - 2009 19156837
    12 - 1520 - 317 - 2009 19156837
    12 - 5139 - 486 - 2009 19156837
    9 - 4703 - 363 - 2009 19156837
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly Homo sapiens
    Endocrineparathyroid   highly
    Lymphoid/Immunespleen   highly
    Reproductivemale systemtestis   
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularsmoothvessel highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period perinatal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ETS DNA-binding and helix-loop-helix (HLH) domains
  • HOMOLOGY
    intraspecies homolog to avian erythroblastosis virus E26 (v-ets) oncogene
    Homologene
    FAMILY
  • Ets family of transcription factors
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text its protein expression is predominantly found in prostate carcinomas with ERG gene rearrangement and does not occur in benign glands
    basic FUNCTION
  • transcription regulator, through SETDB1-mediated histone methylation
  • required for endothelial tube formation
  • involved in a new pathway regulating angiogenesis and endothelial survival, via the adhesion molecule VE-cadherin
  • is at the center of a distinct regulatory program that is not required for hematopoietic specification or differentiation but is critical for hematopoietic stem cell maintenance during embryonic development
  • Ets-transcription factor required for normal blood stem cell development
  • promotes T-ALL (T-acute lymphoblastic leukemia) and failure to extinguish activity of stem cell enhancers associated with regulatory transcription factors such as ERG can contribute to the development of leukemia
  • plays a pivotal role in regulating endothelial cells (EC) barrier function and this effect is mediated in part through its regulation of CLDN5 gene expression
  • role for ERG as a gatekeeper controlling vascular inflammation, thus providing an important barrier to protect against inappropriate endothelial activation
  • in primary leukemic cells, ERG may contribute to the dysregulation of kinase signaling, which results in resistance to kinase inhibitors
  • is critically important for maintenance of the hematopoietic stem cell population
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SETDB1
  • WNT11 is a direct target of ERG (potent ERG induction promoted morphological transformation through WNT11 signals
  • from the fetal period, ERG acts as a direct upstream regulator of GATA2 and RUNX1 gene activity
  • CLDN5 is a downstream target of ERG in EC
  • TDRD1 is the first identified upregulated direct ERG target gene that is strongly associated with ERG overexpression in primary prostate cancer
  • ERG redirects AR to a set of genes including SOX9 that are not normally androgen stimulated, and SOX9 is a critical downstream effector of ERG in TMPRSS2:ERG fusion-positive prostate cancer (PCa)
  • LEF1 is a direct target of ERG and LEF1 inhibition fully abolished ERG-induced WNT signaling and target gene expression
  • SPOP functions as a tumor suppressor to negatively regulate the stability of the ERG oncoprotein in prostate cancer
  • ERG is recruited to mRNAs via interaction with RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    Loss of PTEN and concomitant activation of AKTcould act in partnership with the TMPRSS2-ERG fusion protein to promote progression to prostatecancer
    tumoral     --over  
    overexpression in prostate tumor cells may contribute to the neoplastic process by activating MYC and by abrogating prostate epithelial differentiation as indicated by prostate epithelial specific markers
    tumoral fusion      
    NDRG1-ERG fusion in prostate carcinoma is predicted to encode a chimeric protein
    tumoral fusion      
    TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia (P
    tumoral     --over  
    may deregulate several signaling cascades in acute leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS