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FLASH GENE
Symbol CBR1 contributors: mct - updated : 02-02-2008
HGNC name carbonyl reductase 1
HGNC id 1548
Location 21q22.13      Physical location : 37.442.284 - 37.445.462
Synonym name
  • carbonyl reductase (NADPH) 1
  • prostaglandin 9-ketoreductase
  • prostaglandin-E(2) 9-reductase
    • Synonym symbol(s) CRN, CBR, hCBR1
    EC.number 1.1.1.184, 1.1.1.89, 1.1.1.197
    DNA
    TYPE like-sequence
    STRUCTURE 3.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure XRE elements mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor
    MAPPING cloned Y linked Y status confirmed
    Map seeRUNX1 ,DCR
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1245 - 277 - Colombe (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousbrain   highly
     nerve   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Cbr1
    homolog to C.elegans F20G2.1
    Homologene
    FAMILY short chain dehydrogenases/reductases (SDR) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • NADPH-dependent oxidoreductase
  • metabolizing endogenous and xenobiotic substrates such as the fever mediator, prostaglandin E2 (PGE2), and the anticancer anthracycline drug, daunorubicin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , lipid/lipoprotein
    signaling
    metabolism of many carbonyl compounds, including antitumor anthracycline antibiotics
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
    cell & other
    REGULATION
    induced by BHA,beta-naphthoflavone,sudan 1
    Other regulated by the aryl hydrocarbon receptor (AHR)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Down Syndrome (DS) and Alzheimer's Disease (AD) brains
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS