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FLASH GENE
Symbol B3GALT5 contributors: - updated : 17-11-2003
HGNC name UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
HGNC id 920
Location 21q22.3      Physical location : 41.029.253 - 41.034.815
Synonym name UDP galactose : beta-N-acetylglutamine beta 1,3-galactosyltransferase
EC.number 2.4.1.-
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
motif Viral sequence   long terminal repeat
text structure
  • one coding exon
  • LTR in the promoter activated by HNF1A in the colon and mammary gland
  • MAPPING cloned Y linked   status provisional
    Physical map
    KCNJ6 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 6 DSCR4 21q22.2 Down syndrome critical region gene 4 DSCR8 21q22.2 Down syndrome critical region gene 8 DSCR10 21q22.2 Down syndrome critical region gene 10 KCNJ15 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 15 LOC388824 21 LOC388824 ERG 21q22.2 v-ets erythroblastosis virus E26 oncogene like (avian) ETS2 21q22.3 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) LOC391282 21 similar to 60S ribosomal protein L23a PCBP2P1 21q22.3 poly(rC) binding protein 2, pseudogene 1 DSCR2 21q22.3 Down syndrome critical region gene 2 C21orf107 21 chromosome 21 open reading frame 107 C21orf87 21q22.1 chromosome 21 open reading frame 87 HMGN1 21q22.3 high-mobility group nucleosome binding domain 1 WRB 21q22.3 tryptophan rich basic protein MGC33295 21q22.2 hypothetical protein MGC33295 SH3BGR 21q22.3 SH3 domain binding glutamic acid-rich protein B3GALT5 21q22.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 LOC388825 21 LOC388825 LOC150084 21q22.2 hypothetical protein LOC150084 PCP4 21q22.2-q22.3 Purkinje cell protein 4 DSCAM 21q22.2-q22.3 Down syndrome cell adhesion molecule LOC388826 21 LOC388826 BACE2 21q22.3 beta-site APP-cleaving enzyme 2 PLAC4 21 placenta-specific 4 FAM3B 21q22.3 family with sequence similarity 3, member B MX2 21q22.3 myxovirus (influenza virus) resistance 2 (mouse) MX1 21q22.3 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) TMPRSS2 21q22.3 transmembrane protease, serine 2 C21orf129 21q22.3 chromosome 21 open reading frame 129 ANKRD3 21q22.3 ankyrin repeat domain 3
    RNA
    TRANSCRIPTS type messenger
    text five transcripts differing for the 5'utr and encoding an identical protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - initiation site 2760 36 310 - Ishikishi
    including exons 1, 3, 4
    - initiation site 2630 36 310 - Ishikishi
    including exons 1', 3, 4
    - initiation site - 36 310 trace amounts Ishikishi
    exons 1, 2, 3, 4
    - initiation site 2710 36 - trace amounts Ishikishi
    exons 1, 2, 4
    - - - - - - Ishikishi
    exons 1, 3, 4 intron IV3
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     stomach    
    Endocrinepancreas    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines adenocarcinoma cell lines (Colo205)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • mucin glycosylation with a preference for the core 3-O-glycosylation
  • catalyzing by N-acetylglucosamine-beta-1,3-galactosyltransferase (beta-3-GalT), which transfers a galactose to an N-acetylglucosamine with a beta-1,3-linkage, resulting in the synthesis of a type 1 Lewis chain.
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • most probable candidate responsible for the synthesis of the type I Lewis antigen in gastrointestinal and pancreatic epithelia and tumor cells derived thereform. Key enzyme that determines the amount of type I Lewis antigen
  • including the sialyl Lewis a antigen
  • PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by TCF1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS