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FLASH GENE
Symbol ETS2 contributors: mct/npt/shn - updated : 04-12-2015
HGNC name v-ets avian erythroblastosis virus E26 oncogene homolog 2
HGNC id 3489
Location 21q22.2      Physical location : 40.177.848 - 40.196.876
Synonym name
  • v-ets avian erythroblastosis virus E26 oncogene homolog 2
  • oncogene ETS-2
  • ETS2 intronic transcript 1
  • protein C-ets-2
  • v-ets avian erythroblastosis virus E2 oncogene homolog 2
  • Synonym symbol(s) ETS2IT1
    DNA
    TYPE functioning gene
    STRUCTURE 19.03 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D21S1883 - D21S1255 - ETS2 - D21S1891 - D21S268 - qter
    Authors Hubert (97), Vidal-Taboada (98)
    Text [ ]:DSCR2 critical region
    Physical map
    SIM2 21q22.2 single-minded homolog 2 (Drosophila) HLCS 21q22.2 holocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) MRPL20P1 21q22.2 holocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) DSCR6 21q22.2 Down syndrome critical region gene 6 DSCR5 21q22.2 Down syndrome critical region gene 5 TTC3 21q22.2 tetratricopeptide repeat domain 3 DSCR9 21q22.13 Down syndrome critical region gene 9 DSCR3 21q22.3 Down syndrome critical region gene 3 DYRK1A 21q22.2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A KCNJ6 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 6 DSCR4 21q22.2 Down syndrome critical region gene 4 DSCR8 21q22.2 Down syndrome critical region gene 8 DSCR10 21q22.2 Down syndrome critical region gene 10 KCNJ15 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 15 LOC388824 21 LOC388824 ERG 21q22.2 v-ets erythroblastosis virus E26 oncogene like (avian) ETS2 21q22.3 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) LOC391282 21 similar to 60S ribosomal protein L23a PCBP2P1 21q22.3 poly(rC) binding protein 2, pseudogene 1 DSCR2 21q22.3 Down syndrome critical region gene 2 C21orf107 21 chromosome 21 open reading frame 107 C21orf87 21q22.1 chromosome 21 open reading frame 87 HMGN1 21q22.3 high-mobility group nucleosome binding domain 1 WRB 21q22.3 tryptophan rich basic protein MGC33295 21q22.2 hypothetical protein MGC33295 SH3BGR 21q22.3 SH3 domain binding glutamic acid-rich protein B3GALT5 21q22.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 LOC388825 21 LOC388825 LOC150084 21q22.2 hypothetical protein LOC150084 PCP4 21q22.2-q22.3 Purkinje cell protein 4 DSCAM 21q22.2-q22.3 Down syndrome cell adhesion molecule
    RNA
    TRANSCRIPTS type messenger
    text promoter region of ETS2 does not possess typical "TATA" and "CAAT" elements but contains several repeat regions, two consensus AP2 binding sites and three putative Sp1 sites PMID:2405393
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 3684 - 469 - -
    10 splicing 3954 - 609 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines HL60, HeLa, K562, Mott4, B.L.Raji, SW48, A549, G361
    fluid/secretion
    at STAGE
    physiological period embryo
    Text endocardium, endothelium
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a DNA-binding domain at the N-terminus and a repression domain at the C-terminus
  • HOMOLOGY
    interspecies homolog to avian erythroblastosis virus E26 (v-ets) oncogene 2
    ortholog to Ets2, Mus musculus
    ortholog to Ets2, Rattus norvegicus
    ortholog to ets2, Danio rerio
    ortholog to ETS2, Pan troglodytes
    Homologene
    FAMILY
  • ETS family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcription regulator, activating stromelysin-1 (MMP3) collagenase 1 (MMP8), and CDKN2A promoters
  • a role in skeletal development
  • likely involved in skeletal development and required to maintain the transformed state of human prostate cancer cells (role with TP53 in pathological processes of oncogenesis)
  • transcriptional regulator of beta-APP playing a role in the regulation of neuronal apootosis and in the brain pathology of Down syndrome
  • essential for trophoblast stem (TS) cells self-renewal
  • key regulatory factor in the transcriptional control of DUSP6 in responding to activity of MAPK1 (Furukawa 2008)
  • essential for the normal progression of the adipocyte differentiation program in vitro and is a transcription factor in adipogenesis
  • ETS2 has a critical role in directing cardiac progenitors during cardiopoiesis in embryonic stem cells
  • ETS2 and MESP1 play important roles in a genetic network that governs cardiopoiesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • interleukin-5 promoter
  • -10 Ets element PS1 promoter
  • RNA
    small molecule
    protein
  • p300/cAMP-responsive element-binding protein
  • STAT5
  • glucocorticoid receptor, GR
  • Cdk10
  • Brg-1, BAF57/p50 and Ini1
  • EAPII
  • co-repressor BS69
  • Ets-1, SRC-1 and AIB1
  • CDK10 is a protein kinase that partners with CCNQ to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth
  • cell & other
    REGULATION
    Other ID1 inhibits CDKN2A activation by ETS2 (and ETS1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with less than 2-fold Ets2 overexpression in particular organs develop neurocranial, viscerocranial and cervical skeletal abnormalities
  • ETS2 overexpression transgenic mouse develops a smaller thymus and lymphocyte abnormalities
  • Inactivation of Ets2 results in mouse trophoblast stem (TS) cell slower growth, increased expression of a subset of differentiation-associated genes and decreased expression of several genes implicated in TS self-renewal