Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SH3BGR contributors: - updated : 29-04-2004
HGNC name SH3 domain binding glutamic acid-rich protein
HGNC id 10822
Location 21q22.3      Physical location : 40.817.796 - 40.887.426
Synonym symbol(s) ERP,GARP21,SH3B
DNA
TYPE functioning gene
STRUCTURE 63.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas   highly
Nervousbrain    
Reproductivemale systemprostate  highly
Respiratorylung    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline-rich region containing the consensus sequence of a SH3 domain
  • a carboxy-terminal glutamic acid rich region,putatively assuming a coiled-coil structure
    • HOMOLOGY
    interspecies homolog to murine Sh3brg
    homolog to C.elegans ZK856.10
    homolog to C.elegans R05F9.10
    Homologene
    FAMILY SH3BRG family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION SH3/SH2 adaptor protein,involved in protein complex assembly
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component maybe a part of a multimeric complex (Scartezzini,97)
    INTERACTION
    DNA
    RNA
    small molecule
    protein SH3 domain binding
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS