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FLASH GENE
Symbol SH3BGR contributors: - updated : 29-04-2004
HGNC name SH3 domain binding glutamic acid-rich protein
HGNC id 10822
Location 21q22.3      Physical location : 40.817.796 - 40.887.426
Synonym symbol(s) ERP,GARP21,SH3B
DNA
TYPE functioning gene
STRUCTURE 63.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
DYRK1A 21q22.2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A KCNJ6 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 6 DSCR4 21q22.2 Down syndrome critical region gene 4 DSCR8 21q22.2 Down syndrome critical region gene 8 DSCR10 21q22.2 Down syndrome critical region gene 10 KCNJ15 21q22.2 potassium inwardly-rectifying channel, subfamily J, member 15 LOC388824 21 LOC388824 ERG 21q22.2 v-ets erythroblastosis virus E26 oncogene like (avian) ETS2 21q22.3 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) LOC391282 21 similar to 60S ribosomal protein L23a PCBP2P1 21q22.3 poly(rC) binding protein 2, pseudogene 1 DSCR2 21q22.3 Down syndrome critical region gene 2 C21orf107 21 chromosome 21 open reading frame 107 C21orf87 21q22.1 chromosome 21 open reading frame 87 HMGN1 21q22.3 high-mobility group nucleosome binding domain 1 WRB 21q22.3 tryptophan rich basic protein MGC33295 21q22.2 hypothetical protein MGC33295 SH3BGR 21q22.3 SH3 domain binding glutamic acid-rich protein B3GALT5 21q22.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 LOC388825 21 LOC388825 LOC150084 21q22.2 hypothetical protein LOC150084 PCP4 21q22.2-q22.3 Purkinje cell protein 4 DSCAM 21q22.2-q22.3 Down syndrome cell adhesion molecule LOC388826 21 LOC388826 BACE2 21q22.3 beta-site APP-cleaving enzyme 2 PLAC4 21 placenta-specific 4 FAM3B 21q22.3 family with sequence similarity 3, member B MX2 21q22.3 myxovirus (influenza virus) resistance 2 (mouse) MX1 21q22.3 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) TMPRSS2 21q22.3 transmembrane protease, serine 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas   highly
Nervousbrain    
Reproductivemale systemprostate  highly
Respiratorylung    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline-rich region containing the consensus sequence of a SH3 domain
  • a carboxy-terminal glutamic acid rich region,putatively assuming a coiled-coil structure
  • HOMOLOGY
    interspecies homolog to murine Sh3brg
    homolog to C.elegans ZK856.10
    homolog to C.elegans R05F9.10
    Homologene
    FAMILY SH3BRG family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION SH3/SH2 adaptor protein,involved in protein complex assembly
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component maybe a part of a multimeric complex (Scartezzini,97)
    INTERACTION
    DNA
    RNA
    small molecule
    protein SH3 domain binding
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS