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FLASH GENE
Symbol MX1 contributors: mct - updated : 14-10-2009
HGNC name myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
HGNC id 7532
Location 21q22.3      Physical location : 42.792.519 - 42.831.140
Synonym name
  • interferon-induced protein p78
  • interferon-regulated resistance GTP-binding protein MxA
  • myxovirus resistance protein 1
  • Synonym symbol(s) IFI78, MX, MxA, IFI-78K
    DNA
    TYPE functioning gene
    STRUCTURE 38.62 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see ETS2 , TFF1
    Physical map
    LOC388826 21 LOC388826 BACE2 21q22.3 beta-site APP-cleaving enzyme 2 PLAC4 21 placenta-specific 4 FAM3B 21q22.3 family with sequence similarity 3, member B MX2 21q22.3 myxovirus (influenza virus) resistance 2 (mouse) MX1 21q22.3 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) TMPRSS2 21q22.3 transmembrane protease, serine 2 C21orf129 21q22.3 chromosome 21 open reading frame 129 ANKRD3 21q22.3 ankyrin repeat domain 3 PRDM15 21q22.3 PR domain containing 15 LOC388827 21 similar to ZNF298 C21orf25 21q22.3 chromosome 21 open reading frame 25 LOC388828 21 similar to C21orf258 ZNF295 21q22.3 zinc finger protein 295 C21orf121 21 chromosome 21 open reading frame 121 C21orf128 21q22.3 chromosome 21 open reading frame 128 FLJ36335 21q22.3 hypothetical protein FLJ36335 ABCG1 21q22.3 ATP-binding cassette, sub-family G (WHITE), member 1 TFF3 21q22.3 trefoil factor 3 (intestinal) TFF2 21q22.3 trefoil factor 2 (spasmolytic protein 1) TFF1 21q22.3 trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) TMPRSS3 21q22.3 transmembrane protease, serine 3 UBASH3A 21q22.3 ubiquitin associated and SH3 domain containing, A TSGA2 21q22.3 testes specific A2 homolog (mouse)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3409 - 662 - 2009 19297326
    17 - 2983 - 662 - 2009 19297326
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a tripartite GTP-binding domain consisting of GxxxxGKS, DxxG and TKxD
  • HOMOLOGY
    interspecies ortholog to murine Mx2
    ortholog to rattus mx2
    intraspecies homolog to MX2
    Homologene
    FAMILY
  • dynamin family
  • family of large GTPases
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GTPase
  • induction of apoptosis
  • regulatory protein involved in Ca2+ signaling
  • showing activity against influenza virus and vesicular stomatitis virus (VSV) a rhabdovirus
  • recognizes the viral nucleocapsid protein and interferes with its role in viral genome replication
  • having certain characteristics of the stress proteins
  • inhibits tumor cell motility and invasion
  • MX1 and MX2 are intracellular proteins that are induced exclusively by type I IFNs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • self-assemble into homo-oligomers in vitro
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • GTP
  • mg2+
  • protein
  • binding to elements of the cytoskeleton, such as actin and tubulins
  • interacts with the second ankyrin-like repeat domain of TRPC6 and interacted with TRPC1, -3, -4, -5, and -7 (regulated the activity of TRPC6 by a mechanism requiring GTP binding)
  • cell & other
    REGULATION
    induced by interferons (alpha and beta at least)
    by small molecules
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in end-stage dilated cardiomyopathy
    tumoral     --low  
    by hypermethylation in head and neck tumors
    constitutional     --other  
    in multiple sclerosis, MX1 and MX2 proteins are detectable in plaques suggesting endogenous synthesis of type I IFNs as part of the acute inflammatory process
    Susceptibility susceptibility factor for alopecia areata
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    its expression can be induced by small molecules, potentially offering a new approach to the prevention and treatment of metastasis
    ANIMAL & CELL MODELS