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FLASH GENE
Symbol TMPRSS2 contributors: mct/pgu - updated : 09-09-2010
HGNC name transmembrane protease, serine 2
HGNC id 11876
Location 21q22.3      Physical location : 42.836.478 - 42.880.085
Synonym name
  • epitheliasin
  • serine protease 10
  • Synonym symbol(s) PRSS10, TMS2, PP9284, FLJ41954
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    STRUCTURE 43.61 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   HRE
    text structure
  • initiator-like element and potential regulatory element including SREBP, SP1, ERE
  • androgen-responsive promoter elements
  • MAPPING cloned Y linked N status provisional
    Map cen - ERG - MX1 - TMPRSS2 - D21S56 - qter
    Authors PMID: 9325052
    Physical map
    LOC388826 21 LOC388826 BACE2 21q22.3 beta-site APP-cleaving enzyme 2 PLAC4 21 placenta-specific 4 FAM3B 21q22.3 family with sequence similarity 3, member B MX2 21q22.3 myxovirus (influenza virus) resistance 2 (mouse) MX1 21q22.3 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) TMPRSS2 21q22.3 transmembrane protease, serine 2 C21orf129 21q22.3 chromosome 21 open reading frame 129 ANKRD3 21q22.3 ankyrin repeat domain 3 PRDM15 21q22.3 PR domain containing 15 LOC388827 21 similar to ZNF298 C21orf25 21q22.3 chromosome 21 open reading frame 25 LOC388828 21 similar to C21orf258 ZNF295 21q22.3 zinc finger protein 295 C21orf121 21 chromosome 21 open reading frame 121 C21orf128 21q22.3 chromosome 21 open reading frame 128 FLJ36335 21q22.3 hypothetical protein FLJ36335 ABCG1 21q22.3 ATP-binding cassette, sub-family G (WHITE), member 1 TFF3 21q22.3 trefoil factor 3 (intestinal) TFF2 21q22.3 trefoil factor 2 (spasmolytic protein 1) TFF1 21q22.3 trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) TMPRSS3 21q22.3 transmembrane protease, serine 3 UBASH3A 21q22.3 ubiquitin associated and SH3 domain containing, A TSGA2 21q22.3 testes specific A2 homolog (mouse)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3212 53.7 492 - 2001 11322890
    - - 3250 57.6 529 - 2001 11322890
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
     stomach   lowly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell
    cell lineage
    cell lines cells of epithelial prostate carcinoid
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lung, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a serine protease domain of the S1 family
  • a scavenger receptor cysteine rich (SRCR) domain
  • an LDL receptor class A (LDLRA) domain
  • a predicted transmembrane domain
  • HOMOLOGY
    intraspecies homolog to enteropeptidase gene
    Homologene
    FAMILY
  • serine protease, peptidase family
  • peptidase S1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text type II transmembrane-bound serine protease
    basic FUNCTION
  • may contribute to prostate tumour metastasis via the activation of F2RL1
  • important role for TMPRSS2 and possibly TMPRSS4 in influenza virus replication and highlight the former protease as a potential therapeutic target
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate carcinoma, with down-regulation of KLK11 gene in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness
    tumoral fusion      
    with ERG, ETV1 and ETV4 in prostate cancer
    tumoral somatic mutation translocation    
    Loss of PTEN and concomitant activation of AKTcould act in partnership with the TMPRSS2-ERG fusion protein to promote progression to prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS