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FLASH GENE
Symbol FAM3B contributors: SGE/npt - updated : 05-01-2007
HGNC name family with sequence similarity 3, member B
HGNC id 1253
Location 21q22.3      Physical location : 42.688.660 - 42.729.654
Synonym name
  • similar to 2-19 protein
  • cytokine-like protein 2.21
  • chromosome 21 open reading frame 11
  • pancreatic derived factor
  • Synonym symbol(s) PRED44, ORF9, 2-21, C21orf11, C21orf76, PANDER, D21M16SJHU19e
    DNA
    TYPE functioning gene
    STRUCTURE 40.94 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - BACE2 - FAM3B - MX2 - qter
    Authors Reymond (01)
    Physical map
    LOC388826 21 LOC388826 BACE2 21q22.3 beta-site APP-cleaving enzyme 2 PLAC4 21 placenta-specific 4 FAM3B 21q22.3 family with sequence similarity 3, member B MX2 21q22.3 myxovirus (influenza virus) resistance 2 (mouse) MX1 21q22.3 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) TMPRSS2 21q22.3 transmembrane protease, serine 2 C21orf129 21q22.3 chromosome 21 open reading frame 129 ANKRD3 21q22.3 ankyrin repeat domain 3 PRDM15 21q22.3 PR domain containing 15 LOC388827 21 similar to ZNF298 C21orf25 21q22.3 chromosome 21 open reading frame 25 LOC388828 21 similar to C21orf258 ZNF295 21q22.3 zinc finger protein 295 C21orf121 21 chromosome 21 open reading frame 121 C21orf128 21q22.3 chromosome 21 open reading frame 128 FLJ36335 21q22.3 hypothetical protein FLJ36335 ABCG1 21q22.3 ATP-binding cassette, sub-family G (WHITE), member 1 TFF3 21q22.3 trefoil factor 3 (intestinal) TFF2 21q22.3 trefoil factor 2 (spasmolytic protein 1) TFF1 21q22.3 trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) TMPRSS3 21q22.3 transmembrane protease, serine 3 UBASH3A 21q22.3 ubiquitin associated and SH3 domain containing, A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1384 25.9 235 - Reymond, Yang
  • isoform A
  • 7 - 1240 - 187 - Reymond, Yang
  • isoform B
  • - - - - 274 - Reymond
    also called C21orf11-IA
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     stomach   highly
    Endocrineneuroendocrinepituitary   
     pancreas   highly
    Reproductivefemale systembreastmammary gland  
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • one hydrophobic leader sequence
  • four conserved cysteine
  • two glycosylation sites
  • secondary structure 4 alpha-helical bundles with an up-up-down-down topology, and two disulfide bonds (helices B and C and the second disulfide bond are essential for PANDER-induced beta-cell death)
    HOMOLOGY
    interspecies homolog to murine Orf9
    intraspecies homolog to FAM3C
    Homologene
    FAMILY
  • FAM3 family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be having a role in the process of pancreatic beta-cell apoptosis
  • may play a role in glucose homeostasis in combination with or without insulin
  • cytokine, present in insulin secretory granules, inducing apoptosis of alpha and beta cells islets in a dose- and time-dependent manner, and may be implicated in diabetes
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to the liver cell membrane (Yang 2009)
  • REGULATION
    inhibited by over-expression of CLN3 in neuroblastoma cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in diabetes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS