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FLASH GENE
Symbol MX2 contributors: mct - updated : 14-05-2014
HGNC name myxovirus (influenza virus) resistance 2 (mouse)
HGNC id 7533
Location 21q22.3      Physical location : 42.733.949 - 42.780.869
Synonym name interferon-regulated resistance GTP-binding protein MXB
Synonym symbol(s) MXB
DNA
TYPE functioning gene
STRUCTURE 46.92 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status tentative : very preliminary evidence
Map see TFF1
Physical map
LOC388826 21 LOC388826 BACE2 21q22.3 beta-site APP-cleaving enzyme 2 PLAC4 21 placenta-specific 4 FAM3B 21q22.3 family with sequence similarity 3, member B MX2 21q22.3 myxovirus (influenza virus) resistance 2 (mouse) MX1 21q22.3 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) TMPRSS2 21q22.3 transmembrane protease, serine 2 C21orf129 21q22.3 chromosome 21 open reading frame 129 ANKRD3 21q22.3 ankyrin repeat domain 3 PRDM15 21q22.3 PR domain containing 15 LOC388827 21 similar to ZNF298 C21orf25 21q22.3 chromosome 21 open reading frame 25 LOC388828 21 similar to C21orf258 ZNF295 21q22.3 zinc finger protein 295 C21orf121 21 chromosome 21 open reading frame 121 C21orf128 21q22.3 chromosome 21 open reading frame 128 FLJ36335 21q22.3 hypothetical protein FLJ36335 ABCG1 21q22.3 ATP-binding cassette, sub-family G (WHITE), member 1 TFF3 21q22.3 trefoil factor 3 (intestinal) TFF2 21q22.3 trefoil factor 2 (spasmolytic protein 1) TFF1 21q22.3 trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) TMPRSS3 21q22.3 transmembrane protease, serine 3 UBASH3A 21q22.3 ubiquitin associated and SH3 domain containing, A
RNA
TRANSCRIPTS type messenger
text an alternate translation start codon
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 78 - localized in a granular pattern in the heterochromatin region beneath the nuclear envelope 1996 8798556
a nuclear localization signal (NLS) is present at the amino terminal end
14 initiation site 2961 82 715 cytoplasmic form 1996 8798556
lacking the nuclear localization signal (NLS) due to use of an alternate translation start codon
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   highly
Cardiovascularheart    
Endocrinepancreas    
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate   
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear localization signal (NLS) is present at the N-terminal end of the nuclear form but is lacking in the cytoplasmic form, basic nuclear localization signal (NLS) contained within its N-terminal 25 amino acids, and strictly required for antiviral activity
  • a GED domain
  • HOMOLOGY
    interspecies homolog to murine Mx2 and Mx1
    homolog to C.elegans T12E12.4
    intraspecies homolog to MX2
    Homologene
    FAMILY
  • dynamin family
  • IFN-inducible guanosine triphosphatase (GTPase) superfamily
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text
  • having a nuclear and a cytoplasmic form
  • the nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope
  • only MX2 is localized to the nucleus (not MX1) (PmID: 24121441)
  • basic FUNCTION
  • is a narcolepsy-specific dysregulated gene, and there exists a relationship between the HLA-DQB1*0602 allele and MX2 gene expression
  • MX1 and MX2 are intracellular proteins that are induced exclusively by type I IFNs
  • potent inhibitor of HIV-1 infection and as a key effector of IFNA2-mediated resistance to HIV-1 infection, but is ineffective against influenza virus
  • MX2 inhibits the nuclear accumulation and integration of HIV-1 reverse transcripts
  • inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes
  • is an effector in the anti-HIV-1 activity of type I IFN
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
    cell & other
    REGULATION
    activated by by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1
    induced by interferon-alpha
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    in multiple sclerosis, MX1 and MX2 proteins are detectable in plaques suggesting endogenous synthesis of type I IFNs as part of the acute inflammatory process
    constitutional     --low  
    significantly less expressed in comparison with normal subjects in the white blood cells of narcoleptic patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    purposeful mobilization may represent a new therapeutic approach for the treatment of HIV/AIDS
    ANIMAL & CELL MODELS