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FLASH GENE
Symbol VRK1 contributors: mct/npt - updated : 19-08-2009
HGNC name vaccinia related kinase 1
HGNC id 12718
Corresponding disease
PCH1 pontocerebellar hypoplasia 1
Location 14q32.2      Physical location : 97.263.683 - 97.347.950
Synonym name vaccinia virus B1R-related kinase 1
Synonym symbol(s) MGC117401, MGC138280, MGC142070
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 84.27 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
Map cen - D14S65 - D14S1019 - VRK1 - BDKRB2 - BDKRB1 - D14S267 - YY1 - D14S78 - D14S272 - CKB - AKT1 - qter
Authors Gene Map
Physical map
TCL1A 14q32.1 T-cell leukemia/lymphoma 1A LOC390505 14 similar to Ubiquitin carboxyl-terminal hydrolase 5 (Ubiquitin thiolesterase 5) (Ubiquitin-specific processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T) C14orf132 14q32.2 chromosome 14 open reading frame 132 BDKRB2 14q32.11-q32.12 bradykinin receptor B2 CKS1BP 14q32.31 CDC28 protein kinase regulatory subunit 1B pseudogene BDKRB1 14q32.11-q32.12 bradykinin receptor B1 C14orf103 14q32.31 chromosome 14 open reading frame 103 C14orf129 14q32.31 chromosome 14 open reading frame 129 AK7 14q32.2 adenylate kinase 7 PBPP1 14 prostatic binding protein pseudogene 1 RPL23AP10 14 ribosomal protein L23a pseudogene 10 LOC388009 14 hypothetical gene supported by BC019017 PAPOLA 14q32.1-q32.2 poly(A) polymerase alpha VRK1 14q32.1 vaccinia related kinase 1 LOC388010 14 LOC388010
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1720 - 396 - Kang (2008)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousbrainhindbraincerebellum highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text highly expressed in fetal liver, testis and thymus
  • in fetal brain and cerebellum
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • a dominant epitope located in C-terminal region, between AAs 333 and 396, which is detected by different antibodies (Valbuena 2007)
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • VRK subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text
  • dispersed throughout the cell but not located on mitotic spindle or
    • chromatids during mitosis
  • mainly a nuclear protein, with a small fraction found in the cytoplasm and membrane compartments (Renbaum 2009)
  • most of the intracellular VRK1 protein is nuclear, but in some cells it is also detected in the cytosol, depending on the type of tissue (has a subcellular localization that can be regulated, thus adding an additional level of regulatory complexity to the VRK1 protein) (Valbuena 2007)
    • basic FUNCTION
  • serine/threonine kinase phosphorylating thr-18 of TP 53 and may thereby prevent the interaction between TP53 and MDM2
  • might play a role in cell cycle regulation and is likely to represent the beginning of a new control mechanism of cell cycle, particularly late in the G1-S phase (Santos 2006)
  • regulator of TP53 and other transcription factors related with cellular responses to stress (Valbuena 2007)
  • phosphorylates several transcription factors and is associated with proliferation phenotypes (Valbuena 2008)
  • immediate early response gene required for entry in G1, and due to its implication in normal cell proliferation and division (Valbuena 2008)
  • plays a key role in viral DNA replication (Kang 2008)
  • regulates cell cycle progression in the DNA replication period by inducing cyclin D1 (CCND1) expression (Kang 2008)
  • playing roles in neuronal development and maintenance (Renbaum 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with JUN (activates c-Jun dependent transcription, which is dependent on phosphorylation of Ser63 and Ser73)
  • critical link in the CCND1 gene expression pathway stimulated by Myc overexpression and regulator of CCND1 expression (Kang 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target might be a new target for development of inhibitors of cellular proliferation (Valbuena 2008)
    ANIMAL & CELL MODELS