| protein
| phosphorylating NUR77 within its DNA binding domain |
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inactivating components of the apoptotic machinery including BAD, CASP9 and the transcription factor FKHRL1 |
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GSK3B (AKT1/GSK3B signaling required for axons elongation and branching) |
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interacting with thrombospondin to regulate angiogenesis (AKT-thrombospondin axis) |
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down-regulating the mesenchymal transition and enhanced cell migration induced by IGF-I or EGF stimulation |
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cross-regulating the ERK signaling pathway |
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direct target gene of STAT3 and contributes to STAT3 anti-apoptotic function |
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interacting with BCL2 (functions as an activator of the AKT1 signaling pathway in pancreatic cancer)  |
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binds to PLEKHM3 |
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AKT1 may induce anti-apoptotic signals at least in part through the regulation of the amount and activity of BCL2L2 |
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association with PTK6 occuring through the SH3 domain of PTK6 and is enhanced through SH2 domain-mediated interactions following tyrosine phosphorylation of AKT1 |
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interaction involving IQGAP1, MTOR and AKT1 (IQGAP1 is a scaffold that facilitates MTOR and AKT interaction) |
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interacting with RPS3 (selectively initiates anti-apoptotic defenses and represses programmed cell death by regulation of RPS3 and manipulation of nuclear RPS3) |
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interaction between AKT1 and CFLAR |
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binding of AKT1 (tail region) to VIM (head region) results in Vim Ser39 phosphorylation enhancing the ability of VIM to induce motility and invasion while protecting VIMfrom caspase-induced proteolysis |
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AKT1 and FOXM1 are downstream targets of NOTCH1 signaling |
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interacts with MEN1 (through interaction with AKT1, menin suppresses both AKT1-induced proliferation and antiapoptosis in nonendocrine and endocrine cells) |
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interaction with TBK1 (regulatory mechanism for AKT1 activation mediated by TBK1 and role of AKT1 in TLR-mediated immune responses) |
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TNFRSF4 primarily functions to augment AKT1 signaling in T cells by enhancing the amount of PIK3CD and AKT1 available to the TCR |
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AKT1 is a direct TBK1 substrate that connects TBK1 to prosurvival signaling |
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physiological function of IKBKE/TBK1 in AKT1 regulation and a possible mechanism of IKBKE/TBK1 in oncogenesis by activating AKT1 |
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IKBKE is a critical regulator of AKT1 |
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AKT1 induces senescence in cells via MTOR and TP53 in the absence of DNA damage |
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AKT1 was found to directly interact with MUL1 and to be ubiquitinated by MUL1 |
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role for CYLD in tightly regulating the resolution of lung injury and preventing fibrosis by deubiquitinating AKT1 |
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PROM1 has negative effect on the growth of cells through AKT1-dependent signalling pathway |
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SSPN regulates AKT1 signaling to control UTRN expression |
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DLX3 is a novel target of AKT1 and the activity of DLX3 could be modulated by a novel mechanism involving AKT1 during osteoblast differentiation |
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PHF20 is a novel substrate for AKT1 and its phosphorylation by AKT1 plays an important role in tumorigenesis via regulating of TP53 mediated signaling |
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HOX expression could be controlled by the function of AKT1 through epigenetic modification such as DNA methylation |
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AKT1 activity, mediated in part through MTOR, links RIPK1 to JNK activation and autocrine production of TNF |
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AKT1 phosphorylation and activation of PIKFYVE is likely to be a common feedback mechanism for terminating RTK signaling and reducing receptor abundance |
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ARHGEF3 negatively regulates cell survival and skeletal myoblast differentiation by inhibiting CRTC2 and subsequently the Ser/Thr kinase AKT1 |
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AKT1 mediated TGFB1-induced ACTA2 synthesis through the contractile gene transcription factors myocardin and serum response factor (SRF) |
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PIK3CA activates AKT1, independently of PDPK1, and AKT2 by cooperating with PDPK1 in the insulin signal transduction pathway linked to SLC2A4 translocation |
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AKT1 and its downstream MTOR signaling mediates POMC-induced survival in retinal pigment epithelium cells |
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CARD11 is a novel target for AKT1 phosphorylation, suggesting that AKT1-mediated phosphorylation of CARD11 is an additional regulatory mechanism tuning the NFKB1 response downstream of antigen receptor and co-stimulatory signaling |
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FAM3A plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PIK3CA-AKT1 signaling pathway by way of a Ca(2+) /CALM1-dependent mechanism |
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AKT1 is an inter-mediator between the upstream regulator, ALCAM, and downstream effector, FOXO1, in liver cancer cells |
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AKT1 phosphorylation and regulation of TKT is a nodal point for amino acid control of purine synthesis |
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AKT1 augments STAT3 activity through activation of MTOR and upregulation of LIFR expression |
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both AKT1 and AKT2 are involved in albumin endocytosis, and phosphorylation of DAB2 by AKT induces albumin endocytosis in proximal tubule |
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AKT1/CCDC88A signaling in cancer-associated fibroblasts contributes to tumor progression |
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TNFAIP8L2 inhibited the phosphorylation of AKT1, while promoting the phosphorylation of MAPK14, but had no effect on NFKBIA and ERK pathway |
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phosphorylation of PDE3B by AKT1 is not required for insulin to suppress adipocyte lipolysis |
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CD82 regulated BCL2L12 expression via STAT5A and AKT1 signaling and stimulated proliferation and engrafting of leukemia cells |
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ZNRF1 promotes Wallerian degeneration by degrading AKT1 to induce GSK3B activation |
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SMYD3-mediated methylation of AKT1 at lysine 14 is essential for AKT1 activation |
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TNFAIP8L2 suppressed breast cancer tumorigenesis, growth and metastasis possibly via regulation of the AKT1 and MAPK14 signaling pathways |
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ZP3 regulates AKT1 phosphorylation, lamin binding to the nuclear membrane via AIPL1, and organization of the actin cytoskeleton via DIAPH2 |
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TRIM14 functions as an oncogene by upregulating the AKT1 signaling pathway in osteosarcoma cells |
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AKT1, MAPK1, and IKK1/2 phosphorylate BCL3 |
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DCD5 competitively inhibited interaction between histone deacetylase 3 (HDAC3) and AKT1 |
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C terminus of AKT1, AKT2 and the N terminus of VRK2 facilitate the interaction of Akt and VRK2 in mammalian cells |
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EPS8L3 might likely promote proliferation by hyperactivating the AKT1 signaling pathway and subsequently inhibiting the FOXO1A transcriptional activity |
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DSC3 suppresses Colorectal cell growth through inhibition of AKT1 pathway and regulation of CDH1 |
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SAV1 suppresses AKT1 activation by blocking Akt's movement to plasma membrane |
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TIGAR may promote glioblastoma growth and progression through oxidation resistance and AKT1 activation |
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AKT1 plays an important role in the progression of mitosis in mammalian cells and it does so through the phosphorylation and activation of MASTL |
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SOX2 mediates the expression of HBEGF and FSCN1 by activating AKT1 and CTNNB1 signaling pathways |
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AKT1 and RNF167-mediated CASTOR1 degradation activates MTOR independent of arginine and promotes breast cancer progression |
