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FLASH GENE

Symbol

BDKRB2

contributors: mct - updated : 04-11-2014

HGNC name	bradykinin receptor B2
HGNC id	1030

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q32.2      Physical location : 96.671.134 - 96.710.666
Synonym name	BK-2 receptor
Synonym symbol(s)	BKB2R, BKRB2, B2BKR, B2R, BK2, BK-2, BKR2, BRB2, DKFZp686O088, kB2R

DNA

TYPE	functioning gene
STRUCTURE	39.53 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000623 3 - 4197 NP_000614 44.5 391 - 1995 7779089

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine       Endocrine thyroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth

cells

System Cell Pubmed Species Stage Rna symbol   fibroblast Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	heart, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments (7TM) receptor
	a NPXXY sequence at the end of helix 7 and most likely the intracellular helix 8, linked at the N terminus to the NPXXY sequence by a four-amino acid spacer and anchored at its C terminus through palmitoylated cysteines to the inner leaflet of the plasma membrane , that can serve as an allosteric binding site for small molecule compounds

HOMOLOGY

Homologene

FAMILY

family A of rhodopsin/beya-adrenergic-like) of G protein-coupled receptors (GPCRs)

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION	playing a potentially protective role in kidney against end stage renal disease (ESRD)
	associating with G proteins that activate a phosphatidylinositol-calcium second messenger system
	plays an important role in protecting neurons from damage induced by hypoxia/reoxygenation and this effect may function through the ERK1/2 pathway
	regulates the secretion and biosynthesis of EDN1 through bradykinin in tumor cells, especially melanoma cells
	BDKRB1, BDKRB2 play an essential role in inflammatory process and cardiovascular homeostasis
	inhibition of endocytosis, which stabilized BDKRB1 on the cell surface, inhibited BDKRB1 signaling, whereas BDKRB2 signaling was not perturbed
	plays a critical role in inflammatory responses mediated by activation of the kallikrein-kinin system
	bradykinin exerts its vascular actions via two types of receptors, the non-constitutively expressed bradykinin receptor type 1 (BDKRB1) and the constitutive type 2 receptor (BDKRB2)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	BDKRB2, FGF7 and HIST2H2BE are direct IRX1 targets
	interacts with integrin alpha5beta1 to transactivate epidermal growth factor receptor in kidney cells
	BDKRB1 function can be downregulated by BDKRB2 co-endocytosis and signaling

cell & other

REGULATION

Other

regulated by CALR (calreticulin enhances BDKRB2 maturation and heterodimerization with AGT)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in head and neck cancers suggesting that this pathway is involved in HNSCC tumorigenesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune   blockade of the bradykinin B(2) receptor provides therapeutic benefit in hereditary angioedema

ANIMAL & CELL MODELS