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FLASH GENE
Symbol BDKRB2 contributors: mct - updated : 04-11-2010
HGNC name bradykinin receptor B2
HGNC id 1030
Location 14q32.2      Physical location : 96.671.134 - 96.710.666
Synonym name BK-2 receptor
Synonym symbol(s) BKB2R, BKRB2, B2BKR, B2R, BK2, BK-2, BKR2, BRB2, DKFZp686O088
DNA
TYPE functioning gene
STRUCTURE 39.53 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
C14orf139 14q32.2 chromosome 14 open reading frame 139 C14orf49 14q32.2 chromosome 14 open reading frame 49 C14orf113 14q32.2 chromosome 14 open reading frame 113 C14orf62 14 chromosome 14 open reading frame 62 C14orf87 14q32.2 chromosome 14 open reading frame 87 TCL6 14q32.1 T-cell leukemia/lymphoma 6 TCL1B 14q32.1 T-cell leukemia/lymphoma 1B TCL1A 14q32.1 T-cell leukemia/lymphoma 1A LOC390505 14 similar to Ubiquitin carboxyl-terminal hydrolase 5 (Ubiquitin thiolesterase 5) (Ubiquitin-specific processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T) C14orf132 14q32.2 chromosome 14 open reading frame 132 BDKRB2 14q32.11-q32.12 bradykinin receptor B2 CKS1BP 14q32.31 CDC28 protein kinase regulatory subunit 1B pseudogene BDKRB1 14q32.11-q32.12 bradykinin receptor B1 C14orf103 14q32.31 chromosome 14 open reading frame 103 C14orf129 14q32.31 chromosome 14 open reading frame 129 AK7 14q32.2 adenylate kinase 7 PBPP1 14 prostatic binding protein pseudogene 1 RPL23AP10 14 ribosomal protein L23a pseudogene 10 LOC388009 14 hypothetical gene supported by BC019017 PAPOLA 14q32.1-q32.2 poly(A) polymerase alpha VRK1 14q32.1 vaccinia related kinase 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 4197 44.5 391 - 1995 7779089
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine   
Endocrinethyroid    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth   
cells
SystemCellPubmedSpeciesStageRna symbol
 fibroblast
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text heart, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a NPXXY sequence at the end of helix 7 and most likely the intracellular helix 8, linked at the N terminus to the NPXXY sequence by a four-amino acid spacer and anchored at its C terminus through palmitoylated cysteines to the inner leaflet of the plasma membrane , that can serve as an allosteric binding site for small molecule compounds
  • HOMOLOGY
    Homologene
    FAMILY
  • family A of rhodopsin/beya-adrenergic-like) of G protein-coupled receptors (GPCRs)
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • playing a potentially protective role in kidney against end stage renal disease (ESRD)
  • associating with G proteins that activate a phosphatidylinositol-calcium second messenger system
  • plays an important role in protecting neurons from damage induced by hypoxia/reoxygenation and this effect may function through the ERK1/2 pathway
  • regulates the secretion and biosynthesis of EDN1 through bradykinin in tumor cells, especially melanoma cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BDKRB2, FGF7 and HIST2H2BE are direct IRX1 targets
  • interacts with integrin alpha5beta1 to transactivate epidermal growth factor receptor in kidney cells
  • cell & other
    REGULATION
    Other regulated by CALR (calreticulin enhances BDKRB2 maturation and heterodimerization with AGT)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in head and neck cancers suggesting that this pathway is involved in HNSCC tumorigenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    blockade of the bradykinin B(2) receptor provides therapeutic benefit in hereditary angioedema
    ANIMAL & CELL MODELS