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FLASH GENE
Symbol CKB contributors: mct - updated : 15-04-2015
HGNC name creatine kinase, brain
HGNC id 1991
Location 14q32.32      Physical location : 103.985.995 - 103.989.170
Synonym name
  • creatine kinase B-chain
  • epididymis luminal protein 211
  • epididymis secretory protein Li 29
  • Synonym symbol(s) CKBB, KCRB, B-CK, BCK, HEL-211, HEL-S-29
    EC.number 2.7.3.2
    DNA
    TYPE functioning gene
    STRUCTURE 3.20 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned N linked Y status confirmed
    Physical map
    AMN 14q32.3 amnionless homolog (mouse) CDC42BPB 14q32.3 CDC42 binding protein kinase beta (DMPK-like) C14orf73 14 chromosome 14 open reading frame 73 TNFAIP2 14q32 tumor necrosis factor, alpha-induced protein 2 RPL21P12 14q32.33 ribosomal protein L21 pseudogene 12 RPL21P13 14 ribosomal protein L21 pseudogene 13 RPL17P4 14 ribosomal protein L17 pseudogene 4 LOC388019 14 LOC388019 EIF5 14q32.33 eukaryotic translation initiation factor 5 LAMR1P5 14 laminin receptor 1 pseudogene 5 MARK3 14q32.3 MAP/microtubule affinity-regulating kinase 3 RPL10AP1 14 ribosomal protein L10a pseudogene 1 CKB 14q32.32 creatine kinase, brain FLJ40452 14q32.33 hypothetical protein FLJ40452 BAG5 14q32.32 BCL2-associated athanogene 5 MGC2562 14q32.33 hypothetical protein MGC2562 KNS2 14q32.3 kinesin 2 60/70kDa XRCC3 14q32.3 X-ray repair complementing defective repair in Chinese hamster cells 3 ZFYVE21 14q32.33 zinc finger, FYVE domain containing 21 PPP1R13B 14q32.33 protein phosphatase 1, regulatory (inhibitor) subunit 13B C14orf2 14q32.33 chromosome 14 open reading frame 2 LOC338934 14q32.33 similar to chromosome 1 open reading frame 36 C14orf75 14q32.33 chromosome 14 open reading frame 75
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1475 - 381 - Wang (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ckb
    Homologene
    FAMILY guanido phosphotransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in energy homeostasis
  • reversibly catalyzing the transfer of phosphate between ATP and various phosphogens such as creatine phosphate
  • playing a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
  • playing an important role in the bone-resorbing function of osteoclasts
  • regulates mature osteoclast activity, including the formation and maintenance of the actin sealing ring and the activities of V-ATPase and RhoA
  • contribute to osteoclast function
  • downregulation of CKB may play an important role in colon cancer progression by promoting EMT
  • AMPK and CKB cooperate under energy stress to compensate for loss of adenosine triphosphate (ATP) by either stimulating ATP-generating and inhibiting ATP-consuming pathways
  • localized CKB plays a key role in myotube formation by limiting myoblast fusion during myogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component homodimerizing or heterodimerizing with CKM
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CKB interacts with ASB9 in a specific, SOCS box-independent manner
  • HPCA specifically bound to CKB in a Ca(2+)-dependent manner, but not to the muscle-type CKM subunit
  • ASB9 binds to creatine kinase (CKB) and targets it for degradation
  • cell & other
    REGULATION
    induced by in mature osteoclasts, and by TNFSF11 during osteoclastogenesis
    repressed by PARP1 (activity of PARP1 was determined to be required for its inhibitory effect on the CKB expression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    during osteoclastogenesis
    tumoral     --low  
    in colon cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS