Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BDKRB1 contributors: mct - updated : 16-04-2020
HGNC name bradykinin receptor B1
HGNC id 1029
Location 14q32.2      Physical location : 96.722.558 - 96.731.098
Synonym name
  • bradykinin receptor 1
  • bradykinin receptor B2
    • Synonym symbol(s) BKRB1, B1BKR, B1R, BKB1R, BKR1, BRADYB1, kB1R
    DNA
    TYPE functioning gene
    STRUCTURE 8.55 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure regulatory motifs could exist outside the BDKRB1 gene core promoter region
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1307 - 353 - 2018 29034546
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		seven transmembrane segments (7TM) receptor, lacking the Cter Arg
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a potentially protective role in the kidney against end stage renal disease (ESRD)
  • playing an important role in the control of pancreatic vascular homeostasis and insulin release, and in the pathogenesis of diabetes and related diseases
  • laminar shear stress (LSS) is a major determinant of functional BDKRB1 expression in endothelium
  • BDKRB1, BDKRB2 play an essential role in inflammatory process and cardiovascular homeostasis
  • participates in the modulation of insulin action in adipocytes, contributing to systemic insulin sensitivity and predisposition to obesity
  • G protein-coupled receptor with pro-inflammatory activity that is latent in healthy tissues but induced by tissue insult
  • plays an important role in hepatic steatosis development
  • inhibition of endocytosis, which stabilized BDKRB1 on the cell surface, inhibited BDKRB1 signaling, whereas BDKRB2 signaling was not perturbed
  • BDKRB1-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia
  • regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control
  • BDKRB1, APLNR are involved in a variety of important physiological processes, which share many similar characteristics in distribution and functions in the cardiovascular system
  • is a novel modulator that promotes adhesion of leukocytes to endothelial cells, critically enhancing the movement of neutrophils from the circulation to sites of inflammation
  • plays a critical role in inflammatory responses mediated by activation of the kallikrein-kinin system
  • may contribute to improve the host response against melanoma progression
  • bradykinin exerts its vascular actions via two types of receptors, the non-constitutively expressed bradykinin receptor type 1 (BDKRB1) and the constitutive type 2 receptor (BDKRB2)
  • BDKRB1 and the transient receptor potential ankyrin 1 (TRPA1) work as initiators and gatekeepers of nociception and inflammation
  • detrimental role of BDKRB1 in insulin resistance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • BDKRB1 homo-oligomerization is necessary for BDKRB1 maturation and trafficking to the cell surface
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • close relationship of BDKRB1 and CPM on the membrane is required for efficiently generatingoles in inflammation
  • up-regulation of BDRKB1 may contribute to acute inflammatory pain through TRPV1 activation
  • BDKRB1 function can be downregulated by BDKRB2 co-endocytosis and signaling
  • important role of the endothelial BDKRB1 in the vascular control by interfering with SLC7A1 expression, L-Arg uptake and nitric oxide (NO) release
  • BDKRB1 positively modulates both CPM expression and activity, suggesting that CPM-BDKRB1 interaction in membrane microdomains might affect enzyme activity, beyond interfering in receptors signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in subcutaneous white adipose tissue (sWAT) in patients with coronary artery disease (CAD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum BDKRB1 levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis
    • Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    its inhibition can reduce BBB damage and cell invasion during autoimmune CNS disease and may offer a novel anti-inflammatory strategy for the treatment of MS
    miscelleaneousurinary 
    blockade of the BDKRB1 has significant potential for the treatment of glomerulonephritis
    ANIMAL & CELL MODELS
  • Bdkrb1 is upregulated by the oxidative stress in the brain of insulin-resistant rats and its activation causes stereotypic nocifensive behavior through the release of substance P, glutamate and NO