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FLASH GENE
Symbol BDKRB1 contributors: mct - updated : 19-03-2008
HGNC name bradykinin receptor B1
HGNC id 1029
Location 14q32.11-q32.12      Physical location : 96.722.558 - 96.731.098
Synonym name bradykinin receptor 1
Synonym symbol(s) BKRB1, B1BKR, B1R, BKB1R, BKR1, BRADYB1
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure regulatory motifs could exist outside the BDKRB1 gene core promoter region
MAPPING cloned Y linked Y status provisional
Physical map
C14orf113 14q32.2 chromosome 14 open reading frame 113 C14orf62 14 chromosome 14 open reading frame 62 C14orf87 14q32.2 chromosome 14 open reading frame 87 TCL6 14q32.1 T-cell leukemia/lymphoma 6 TCL1B 14q32.1 T-cell leukemia/lymphoma 1B TCL1A 14q32.1 T-cell leukemia/lymphoma 1A LOC390505 14 similar to Ubiquitin carboxyl-terminal hydrolase 5 (Ubiquitin thiolesterase 5) (Ubiquitin-specific processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T) C14orf132 14q32.2 chromosome 14 open reading frame 132 BDKRB2 14q32.11-q32.12 bradykinin receptor B2 CKS1BP 14q32.31 CDC28 protein kinase regulatory subunit 1B pseudogene BDKRB1 14q32.11-q32.12 bradykinin receptor B1 C14orf103 14q32.31 chromosome 14 open reading frame 103 C14orf129 14q32.31 chromosome 14 open reading frame 129 AK7 14q32.2 adenylate kinase 7 PBPP1 14 prostatic binding protein pseudogene 1 RPL23AP10 14 ribosomal protein L23a pseudogene 10 LOC388009 14 hypothetical gene supported by BC019017 PAPOLA 14q32.1-q32.2 poly(A) polymerase alpha VRK1 14q32.1 vaccinia related kinase 1 LOC388010 14 LOC388010
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1307 - 353 - Bengtson (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor, lacking the Cter Arg
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling cytokine , receptor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • playing a potentially protective role in the kidney against end stage renal disease (ESRD)
  • playing an important role in the control of pancreatic vascular homeostasis and insulin release,and in the pathogenesis of diabetes and related diseases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS