SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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| text
| dispersed throughout the cell but not located on mitotic spindle or |
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chromatids during mitosis |
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mainly a nuclear protein, with a small fraction found in the cytoplasm and membrane compartments  |
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most of the intracellular VRK1 protein is nuclear, but in some cells it is also detected in the cytosol, depending on the type of tissue (has a subcellular localization that can be regulated, thus adding an additional level of regulatory complexity to the VRK1 protein) |
| basic FUNCTION
| serine/threonine kinase phosphorylating thr-18 of TP 53 and may thereby prevent the interaction between TP53 and MDM2 |
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might play a role in cell cycle regulation and is likely to represent the beginning of a new control mechanism of cell cycle, particularly late in the G1-S phase |
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regulator of TP53 and other transcription factors related with cellular responses to stress |
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phosphorylates several transcription factors and is associated with proliferation phenotypes |
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immediate early response gene required for entry in G1, and due to its implication in normal cell proliferation and division |
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plays a key role in viral DNA replication |
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regulates cell cycle progression in the DNA replication period by inducing cyclin D1 (CCND1) expression |
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playing roles in neuronal development and maintenance |
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novel Ser/Thr kinase that is expressed constantly during interphase, and appears to play an important role during this period in the cell cycle |
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important role for VRK1 in cell proliferation and confirm that the need for VRK1 during gametogenesis is evolutionarily conserved |
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can increase cyclin D1 expression via the phosphorylation of the cAMP-response element-binding protein and has a major role in the G1/S transition |
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conserved role for VRK1 in coordinating proper chromosomal configuration in female meiosis |
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controls chromatin condensation by histone phosphorylation, nuclear envelope assembly by phosphorylation of BANF1, and participates in signalling required for Golgi fragmentation late in the G2 phase |
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mitotic kinases that play important roles in cell cycle, nuclear condensation, and transcription regulation |
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VRK1 and VRK2 are atypical active Ser-Thr kinases implicated in control of cell cycle entry, apoptosis and autophagy, and affect signalling by mitogen activated protein kinases (MAPK) |
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play crucial roles in germ cell development |
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required for telomere maintenance via phosphorylation of HNRNPA1, which regulates proteins associated with the telomere and telomerase RNA |
