| basic FUNCTION
| cytoskeleton protein binding to vinculin and integrin |
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concentrating at points of cell adhesion (focal contacts), also substrate for calpa |
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n II |
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is the primary link between integrins and actin in dynamic focal adhesions in undifferentiated, motile cells |
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responding and participating in reorganization of membrane-cytoplasmic interactions |
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link the actin cytoskeleton to the extracellular environment through interactions with beta-integrins and actin |
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essential to integrin activation in platelets |
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required to support coupling of surface-associated fibronectin to the actin cytoskeleton through C-terminal region |
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serves as an essential link between integrins and the actin cytoskeleton in several similar, but functionally distinct, adhesion complexes, including focal adhesions, costameres, and intercalated disks |
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provides a direct link between the integrin family of cell adhesion molecules and the actin cytoskeleton |
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through conserved dimerization motif in the I/LWEQ module, plays an essential role as a component of focal adhesions and, by extension, the other I/LWEQ module proteins in other multicomponent assemblies involved in cell adhesion and vesicle trafficking  |
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TLN1, TLN2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions (MTJs) |
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key integrin coactivator |
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not required for follicular B-cell maturation in the spleen or homeostatic humoral immunity but is critical for integrin-dependent B lymphocyte emigration to lymph nodes and optimal immunity against T-dependent antigens |
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endothelial cell TLN1 is essential for embryonic angiogenesis |
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cytoskeletal protein that binds to integrin beta cytoplasmic tails and regulates integrin activation |
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recruits and activates focal adhesion proteins required for proliferation via the C terminus of its rod domain |
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new function for talin, which is to link integrin adhesions with cell cycle progression |
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adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin |
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plays a key role in cell adhesion and spreading |
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dimeric adaptor protein that associates with the integrin family of cell adhesion molecules in cell-extracellular matrix junctions (focal adhesions) |
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TLN1 and RAP1A are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss |
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TLN1 and TLN2 have distinct functions in the myocardium |
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is essential protein for integrin adhesion |
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would be involved in the integrin-dependent hypertrophic response of the myocardium |
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is not essential in the adult myocardium and its loss from cardiac myocytes (CMs) only leads to a mild stress response |
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appears to be critical in acute costameric force-sensing and mechanical signaling |
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actin-binding proteins TLN1 and VCL cooperate to provide the link between extracellular-matrix-bound integrins and intracellular F-actin, essential for cell spreading and migration |
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