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FLASH GENE
Symbol MLLT3 contributors: mct/ - updated : 29-03-2006
HGNC name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
HGNC id 7136
Location 9p21.3      Physical location : 20.344.967 - 20.622.514
Synonym name
  • AF-9 protein
  • ALL1-fused gene from chromosome 9 protein
  • YEATS domain-containing protein 3
  • myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein
    • Synonym symbol(s) AF9, LTG9, FLJ2035, YEATS3
    DNA
    TYPE functioning gene
    STRUCTURE 277.55 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence scaffold attachement regions/matrix attachement regions
    text structure SAR/MAR, two SARs at the border of AF9 BCR
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC392288 9 similar to microtubule-associated proteins 1A/1B light chain 3 SLC24A2 9p22-p13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 LOC389706 9 LOC389706 SMNP 9 LOC389706 MLLT3 9p22 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 KIAA1797 9p21 KIAA1797 IFNB1 9p22 interferon, beta 1, fibroblast IFNW1 9p22 interferon, omega 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3439 63.2 568 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral lobefrontal 
    Reproductivefemale systemovary  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • serine/proline rich nuclear protein
  • nuclear targeting sequence
  • YEATS domain
    • HOMOLOGY
    interspecies homolog to Drosophila trithorax
    homolog to C.elegans t09d3.3
    intraspecies homolog to MLLT1
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in cell growth and in maintenance, and in oncogenesis
  • required in the elaboration of the erythroid and megakaryocytic lineages (Pina 2008)
  • regulator of early erythroid and megakaryocytic cell fate in the human system (Pina 2008)
    • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with HRX (MLL), in acute myeloid/lymphoid, in monoblastic leukemia with granulocytic sarcomas mixed-lineage leukemia and translocation t(9;11)(p22;q23)
    tumoral   translocation    
    in acute myeloid/lymphoid, monoblastic leukemia
    tumoral   translocation    
    involves MLL, MLLT3, and CCDC94, in the pathogenesis of acute myeloid leukemia with t(9;11;19)(p22;q23;p13.3)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate regulator of erythroid/megakaryocytic (E/Meg) lineage decisions (Pina 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS