Citations for
Wdr1-Dependent Actin Reorganization in Platelet Activation.
Dasgupta SK, Le A, Da Q, Cruz M, Rumbaut RE, Thiagarajan P.
PLoS One 11(9):e0162897. doi: 10.1371/journal.pone.0162897. eCollection 2016. 2016
Vinculin controls talin engagement with the actomyosin machinery.
Atherton P, Stutchbury B, Wang DY, Jethwa D, Tsang R, Meiler-Rodriguez E, Wang P, Bate N, Zent R, Barsukov IL, Goult BT, Critchley DR, Ballestrem C.
Nat Commun 6:10038. doi: 10.1038/ncomms10038. 2015
Talin1 and Rap1 are critical for osteoclast function.
Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg MH, Teitelbaum SL.
Mol Cell Biol 33(4):830-44. doi: 10.1128/MCB.00790-12. Epub 2012 Dec 10. 2013
Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells.
Jevnikar Z, Rojnik M, Jamnik P, Doljak B, Fonovic UP, Kos J.
J Biol Chem 288(4):2201-9. doi: 10.1074/jbc.M112.436394. Epub 2012 Nov 30. 2013
Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.
Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS.
J Biol Chem 288(6):4252-64. doi: 10.1074/jbc.M112.427484. Epub 2012 Dec 24. 2013
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.
Bate N, Gingras AR, Bachir A, Horwitz R, Ye F, Patel B, Goult BT, Critchley DR.
PLoS One 7(4):e34461. doi: 10.1371/journal.pone.0034461. Epub 2012 Apr 4. 2012
Subcellular localization of talin is regulated by inter-domain interactions.
Banno A, Goult BT, Lee H, Bate N, Critchley DR, Ginsberg MH.
J Biol Chem 287(17):13799-812. doi: 10.1074/jbc.M112.341214. Epub 2012 Feb 18. 2012
FAK promotes recruitment of talin to nascent adhesions to control cell motility.
Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD.
J Cell Biol 196(2):223-32. doi: 10.1083/jcb.201108078. Erratum in: J Cell Biol. 2012 Feb 6;196(3):387. 2012
New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ.
Eur J Cell Biol 91(3):180-91. doi: 10.1016/j.ejcb.2011.12.003. Epub 2012 Feb 3. 2012
Endothelial cell talin1 is essential for embryonic angiogenesis.
Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg MH, Pritchard CA, Critchley DR.
Dev Biol 349(2):494-502. Epub 2010 Nov 26. 2011
Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.
Liu J, He X, Qi Y, Tian X, Monkley SJ, Critchley DR, Corbett SA, Lowry SF, Graham AM, Li S.
Mol Cell Biol 31(16):3366-77. Epub 2011 Jun 13. 2011
The C terminus of talin links integrins to cell cycle progression.
Wang P, Ballestrem C, Streuli CH.
J Cell Biol 195(3):499-513. doi: 10.1083/jcb.201104128. 2011
Central region of talin has a unique fold that binds vinculin and actin.
Gingras AR, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC, Critchley DR.
J Biol Chem 285(38):29577-87. Epub 2010 Jul 7. 2010
Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.
Manevich-Mendelson E, Grabovsky V, Feigelson SW, Cinamon G, Gore Y, Goverse G, Monkley SJ, Margalit R, Melamed D, Mebius RE, Critchley DR, Shachar I, Alon R.
Blood 116(26):5907-18. Epub 2010 Oct 5. 2010
Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance.
Sakamoto S, McCann RO, Dhir R, Kyprianou N.
Cancer Res 70(5):1885-95. doi: 10.1158/0008-5472.CAN-09-2833. Epub 2010 Feb 16. 2010
Functional and structural characterization of the talin F0F1 domain.
Domadia PN, Li YF, Bhunia A, Mohanram H, Tan SM, Bhattacharjya S.
Biochem Biophys Res Commun 391(1):159-65. doi: 10.1016/j.bbrc.2009.11.024. Epub 2009 Nov 10. 2010
Dystrophin-glycoprotein complex and vinculin-talin-integrin system in human adult cardiac muscle.
Anastasi G, Cutroneo G, Gaeta R, Di Mauro D, Arco A, Consolo A, Santoro G, Trimarchi F, Favaloro A.
Int J Mol Med 23(2):149-59.PMID: 19148538 2009
18TLN1, TLN2
Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.
Conti FJ, Monkley SJ, Wood MR, Critchley DR, Müller U.
Development 136(21):3597-606. doi: 10.1242/dev.035857. Epub 2009 Sep 30. 2009
The structure of the C-terminal actin-binding domain of talin.
Gingras AR, Bate N, Goult BT, Hazelwood L, Canestrelli I, Grossmann JG, Liu H, Putz NS, Roberts GC, Volkmann N, Hanein D, Barsukov IL, Critchley DR.
EMBO J 27(2):458-69. Epub 2007 Dec 20. 2008
An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.
Oxley CL, Anthis NJ, Lowe ED, Vakonakis I, Campbell ID, Wegener KL.
J Biol Chem 283(9):5420-6. Epub 2007 Dec 21.PMID: 18156175 2008
21TLN1, TLN2
Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle.
Senetar MA, Moncman CL, McCann RO.
Cell Motil Cytoskeleton 64(3):157-73. 2007
Vinculin controls focal adhesion formation by direct interactions with talin and actin.
Humphries JD, Wang P, Streuli C, Geiger B, Humphries MJ, Ballestrem C.
J Cell Biol 179(5):1043-57. 2007
A C-terminal dimerization motif is required for focal adhesion targeting of Talin1 and the interaction of the Talin1 I/LWEQ module with F-actin.
Smith SJ, McCann RO.
Biochemistry 46(38):10886-98. Epub 2007 Aug 28.PMID: 17722883 2007
24TLN1, TLN2
Gene duplication and functional divergence during evolution of the cytoskeletal linker protein talin.
Senetar MA, McCann RO.
Gene 362:141-52. Epub 2005 Oct 10. 2005
25TLN1, TLN2
Characterization of an actin-binding site within the talin FERM domain.
Lee HS, Bellin RM, Walker DL, Patel B, Powers P, Liu H, Garcia-Alvarez B, de Pereda JM, Liddington RC, Volkmann N, Hanein D, Critchley DR, Robson RM.
J Mol Biol 343(3):771-84. 2004
26TLN1, TLN2
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.
Di Paolo G, Pellegrini L, Letinic K, Cestra G, Zoncu R, Voronov S, Chang S, Guo J, Wenk MR, De Camilli P.
Nature 420(6911):85-9. 2002
Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern.
Ben-Yosef T, Francomano CA.
Genomics 62(2):316-9 1999
Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix.
Bass MD, Smith BJ, Prigent SA, Critchley DR.
Biochem J 341 ( Pt 2):257-63 1999
Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2.
Kilgannon P, et al.
Genomics 54 : 328-330. 1998
cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1.
Mizuno T, et al.
J Biol Chem 272 : 1156-1163. 1997
Construction of a radiation hybrid map of chromosome 9p.
Bouzyk M, et al.
Genomics 34 : 187-192. 1996
Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p.
Gilmore AP, Ohanian V, Spurr NK, Critchley DR.
Hum Genet 96(2):221-4. 1995
The cytoskeletal protein talin contains at least two distinct vinculin binding domains.
Gilmore AP, Wood C, Ohanian V, Jackson P, Patel B, Rees DJ, Hynes RO, Critchley DR.
J Cell Biol 122(2):337-47 1993
A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.
Sato N, et al.
J Cell Sci 103 : 131-143. 1992
Sequence and domain structure of talin.
Rees DJG, et al.
Nature 347 : 685-689. 1990
Functional studies of the domains of talin.
Nuckolls GH, Turner CE, Burridge K.
J Cell Biol 110(5):1635-44 1990