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FLASH GENE
Symbol INSL4 contributors: mct - updated : 03-11-2010
HGNC name insulin-like 4 (placenta)
HGNC id 6087
Location 9p24.1      Physical location : 5.231.418 - 5.233.966
Synonym name
  • early placenta insulin-like peptide,clustered with to relaxin gene
  • placentin
    • Synonym symbol(s) EPIL, PLACENTIN
    DNA
    TYPE functioning gene
    STRUCTURE 4.14 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see TLN1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 617 15.4 139 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text early placental cyto and syncytiotrophoblasts, four limbs vertebrae ribs
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans co1b7.5
    Homologene
    FAMILY
  • insulin, relaxin family
    • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • plays an important role in fetal and placental growth
  • may potentially contribute to fetal growth restriction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the placenta of the growth-restricted twin compared to the normally grown sibling, suggesting that it may be linked to a higher level of apoptosis and loss of cell viability
    constitutional     --over  
    highly secreted in women with pathologic conditions of pregnancy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS