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FLASH GENE
Symbol RLN2 contributors: mct - updated : 29-11-2014
HGNC name relaxin 2 (H2)
HGNC id 10027
Location 9p24.1      Physical location : 5.299.867 - 5.304.580
Synonym name relaxin, ovarian, of pregnancy
Synonym symbol(s) H2, RLXH2, bA12D24.1.1, bA12D24.1.2, H2-RLX
DNA
TYPE functioning gene
STRUCTURE 4.75 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   HRE
text structure G (glucocorticoids )RE motif found on the 5'-flanking region
MAPPING cloned Y linked   status provisional
Physical map
RFX3 9p24 regulatory factor X, 3 (influences HLA class II expression) ZNF515 9p24.2 zinc finger protein 515 C9orf70 9p24.2 chromosome 9 open reading frame 70 SLC1A1 9p24 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 C9orf68 9p24.2 chromosome 9 open reading frame 68 HARC 9p24.1 chromosome 9 open reading frame 68 AK3L1 9p24.1-p24.3 adenylate kinase 3 like 1 LOC392282 9 similar to ribosomal protein S5 RCL1 9p24.1-p23 RNA terminal phosphate cyclase-like 1 JAK2 9p24 Janus kinase 2 (a protein tyrosine kinase) INSL6 9p24 insulin-like 6 INSL4 9p24.1-p23.3 insulin-like 4 (placenta) RLN2 9pter-q12 relaxin 2 (H2) RLN1 9pter-q12 relaxin 1 (H1) C9orf46 9p24.1 chromosome 9 open reading frame 46 PDCD1LG1 9p24 programmed cell death 1 ligand 1 PDCD1LG2 9p24.2 programmed cell death 1 ligand 2 KIAA1432 9p24.1 KIAA1432 KIAA1815 9p24 KIAA1815 MLANA 9p24.1 melan-A KIAA2026 9p24.1 KIAA2026 RANBP6 12p13.31 RAN binding protein 6 C9orf26 9p24.1 chromosome 9 open reading frame 26 (NF-HEV) LOC389704 9 similar to Selenoprotein T NYD-SP25 9p24.1 protein kinase NYD-SP25 NIRF 9p24.1 Np95-like ring finger protein C9orf38 9p24.1 chromosome 9 open reading frame 38 GLDC 9p24-p23 glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P) LOC392283 9 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC392284 9 hypothetical gene supported by AK091574 GASC1 9p24-p23 hypothetical gene supported by AK091574 LOC158352 9p24.1 similar to small nuclear ribonucleoprotein E
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 829 21 185 - 2000 10750025
3 - 930 - 117 - 2000 10750025
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovarycorpus luteum  Homo sapiens
Visualeyeanterior segmentconjunctiva   Homo sapiens
 eyelacrimal gland    Homo sapiens
 eyepalpebra    Homo sapiens
 eyeanterior segmentcornea   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a B-chain
  • a connectin C-peptide
  • an A-chain,forming a mature dipeptide (A,B) chains linked by disulfide bond
  • secondary structure
  • two separate polypeptide chains (A-B) that are cross-linked by three disulfide bonds
  • HOMOLOGY
    interspecies ortholog to RLN1
    Homologene
    FAMILY
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    text
  • secreted into the blood
  • basic FUNCTION
  • involved in reproduction (in preterm premature rupture of the membrane)
  • physiological changes leading to parturition
  • may promote the invasive potential of early placental extravillous trophoblasts (EVTs) through up-regulating MMP2, MMP9 mRNAs
  • promoting vasodilatory effects, is a therapy target for the treatment of acute heart failure, and has recently been shown to be highly expressed by cancer cells, aiding in their proliferation, invasiveness and metastasis
  • role for the RLN2 ligand-receptor system at the ocular surface and in the lacrimal apparatus as a potential future therapeutic during wound healing at the ocular surface
  • systemic hormone (sRLN) that is produced by the corpus luteum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by progesterone receptor (PR)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate carcinoma
    constitutional     --low  
    in diabetes patients
    tumoral     --over  
    of RLN2 and S100A4 might be related to the prediction of metastasis potency and poor prognosis for osteosarcoma patients
    Susceptibility
  • to preterm premature rupture of membranes (PPROM)
  • to spontaneous preterm birth (sPTB)
  • Variant & Polymorphism SNP
  • rs4742076 was associated significantly with PPROM
  • SNP rs3758239 was associated with both PPROM and sPTB
  • Candidate gene
    Marker
  • detection of RLN2 and S100A4 might be useful in evaluating the outcome of patients with osteosarcoma
  • Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquiredheart failure
    may offer therapeutic advantages in end-stage heart failure
    ANIMAL & CELL MODELS