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FLASH GENE

Symbol

RLN1

contributors: mct/npt - updated : 13-10-2009

HGNC name	relaxin 1
HGNC id	10026

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9p24.1      Physical location : 5.334.968 - 5.339.873
Synonym name	relaxin 1 (H1)
	preprorelaxin H1
Synonym symbol(s)	RLXH1, bA12D24.3.1, bA12D24.3.2, H1

DNA

TYPE	functioning gene
STRUCTURE	4.90 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   HRE
text structure	G (glucocorticoids )RE motif found on the 5'-flanking region

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006911 2 - 967 NP_008842 - 185 - Samuel (2007)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system prostate

cell lineage
cell lines	in prostate adenocarcinoma, highly
fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, decidua

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a B-chain
	a connecting C-peptide
	an A-chain, forming a mature dipeptide (A,B) chains linked by sisulfide bond

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

ortholog to RLN2

Homologene

FAMILY

insulin family

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	physiological changes leading to parturition
	acting with estrogen to produce dilatation of the birth canal in many mammals and may be involved in remodeling of connective tissues during pregnancy
	function beyond its ability to regulate collagen turnover(Samuel 2007)
	plays an important role in the regulation of airway structure and function (Samuel 2007)
	relaxin signaling plays a role in prostate cancer progression (Feng 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

endothelin B (antagonist of)

cell & other

REGULATION

Other

regulated by progesterone receptor (PR)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate adenocarcinoma constitutional     --over   increased decidual RLN expression may induce a local sterile inflammatory process which potentially contributes to extracellular matrix degradation and weakening of the fetal membranes (Bryant-Greenwood 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS