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FLASH GENE
Symbol RLN1 contributors: mct/npt - updated : 13-10-2009
HGNC name relaxin 1
HGNC id 10026
Location 9p24.1      Physical location : 5.334.968 - 5.339.873
Synonym name
  • relaxin 1 (H1)
  • preprorelaxin H1
    • Synonym symbol(s) RLXH1, bA12D24.3.1, bA12D24.3.2, H1
    DNA
    TYPE functioning gene
    STRUCTURE 4.90 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure G (glucocorticoids )RE motif found on the 5'-flanking region
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 967 - 185 - Samuel (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    cell lineage
    cell lines in prostate adenocarcinoma, highly
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, decidua
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a B-chain
  • a connecting C-peptide
  • an A-chain, forming a mature dipeptide (A,B) chains linked by sisulfide bond
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to RLN2
    Homologene
    FAMILY
  • insulin family
    • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • physiological changes leading to parturition
  • acting with estrogen to produce dilatation of the birth canal in many mammals and may be involved in remodeling of connective tissues during pregnancy
  • function beyond its ability to regulate collagen turnover(Samuel 2007)
  • plays an important role in the regulation of airway structure and function (Samuel 2007)
  • relaxin signaling plays a role in prostate cancer progression (Feng 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • endothelin B (antagonist of)
    • cell & other
    REGULATION
    Other regulated by progesterone receptor (PR)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate adenocarcinoma
    constitutional     --over  
    increased decidual RLN expression may induce a local sterile inflammatory process which potentially contributes to extracellular matrix degradation and weakening of the fetal membranes (Bryant-Greenwood 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS