SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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| text
| only NEK6 obviously localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis |
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localizes to different microtubule-based structures in mitosis  |
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NEK6 and NEK7 are enriched in the centrosome |
| basic FUNCTION
| mitotic histone kinase regulatring chromatin condensation |
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having important function during mitosis and NEK6 kinase is required for metaphase-anaphase transition |
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play important roles at the G2-M transition in nuclear envelope breakdown and centromere separation |
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novel target of the DNA damage checkpoint and the inhibition of its activity is required for proper cell cycle arrest in the G(2)/M phase upon DNA damage |
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contribute to mitotic progression downstream of another NIMA-related kinase, NEK9 |
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play independent roles not only in robust mitotic spindle formation but also potentially in cytokinesis |
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with NEK7 are required for robust mitotic spindle formation and cytokinesis |
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emerge as factor that function at multiple steps of progression through mitosis, as NEK6 and NEK7 have previously been shown to also support mitotic spindle formation and cytokinesis |
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NEK6 and NEK7 might be required for timely nuclear envelope permeabilization during mitotic entry |
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NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response |
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