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FLASH GENE
Symbol NEK6 contributors: mct/npt/pgu - updated : 14-10-2016
HGNC name NIMA (never in mitosis gene a)-related kinase 6
HGNC id 7749
Location 9q33.3      Physical location : 127.019.884 - 127.114.717
Synonym name
  • putative serine-threonine protein kinase
  • protein kinase SID6-1512
  • NimA-related protein kinase 6
  • Synonym symbol(s) SID6-1512
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 94.48 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - DBC1 - LGMD2H - NEK6 - PBX3 - D9S1928 - NPS1 , AK1 AK1 , ENG , FPGS , CACNA1B , DAPK1 , CRAT , ENDOG , STOM - qter
    Physical map
    LOC254973 9q34.11 similar to Olfactory receptor 1L4 (Olfactory receptor 9-E) (OR9-E) (OST046) LOC392390 9 similar to Olfactory receptor 1L6 LOC389789 9 similar to hypothetical protein LOC348235 LOC392391 9 similar to Olfactory receptor 5C1 (Olfactory receptor 9-F) (OR9-F) LOC392392 9 similar to Olfactory receptor 1K1 PDCL 9q12-q13 phosducin-like MNAB 9q34 phosducin-like ZNF482 9q34.11 zinc finger protein 482 ZNF481 9 zinc finger protein 481 GAPCENA 9q33.1-q33.3 zinc finger protein 481 GPR21 9q33 G protein-coupled receptor 21 C9orf45 9q34.11 chromosome 9 open reading frame 45 STRBP 9q34.11 spermatid perinuclear RNA binding protein FLJ38464 9q34.11 hypothetical protein FLJ38464 KIAA1608 9q34.11 KIAA1608 LHX2 9q33-q34.1 LIM homeobox protein 2 NEK6 9q33.3-q34.11 NIMA (never in mitosis gene a)-related kinase 6 PSMB7 9q33-q34 proteasome (prosome, macropain) subunit, beta type, 7 GPR144 9q34.11 G protein-coupled receptor 144 NR5A1 9q33 nuclear receptor subfamily 5, group A, member 1 NR6A1 9q33-q34.1 nuclear receptor subfamily 6, group A, member 1 LOC169611 9q34.11 hypothetical protein LOC169611 LOC158125 9q34.11 similar to DKFZP434C245 protein RPL35 9q34.1 ribosomal protein L35 ARPC5L 9q34.11 actin related protein 2/3 complex, subunit 5-like GOLGA1 9q34.11 golgi autoantigen, golgin subfamily a, 1 FLJ36664 9q34.11 hypothetical protein FLJ36664 PPP6C Xq22.3 protein phosphatase 6, catalytic subunit NDUFB3P2 9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 2 RAB9P40 9q33.1-q33.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 2 HSPA5 9q34 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) LOC392393 9 similar to 40S ribosomal protein S10 DKFZP434C212 9q34.11 DKFZP434C212 protein MAPKAP1 9q34.11-q34.12 mitogen-activated protein kinase associated protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2810 - 347 - 2008 18728393
    10 - 2645 - 313 - 2008 18728393
    - - 2592 - 331 - 2008 18728393
    - - 2587 - 313 - 2008 18728393
    - - 2596 - 338 - 2008 18728393
    - - 2594 - 313 - 2008 18728393
    - - 2759 - 347 - 2008 18728393
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   highly
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • APBB1 WW domain binding motifs ((267)PPLP(270)) in the catalytic domain
  • HOMOLOGY
    interspecies ortholog to Aspergillus nidulans NIMA
    homolog to murine Nek6
    intraspecies paralog to NEK7
    Homologene
    FAMILY
  • protein kinase superfamily
  • NEK Ser/Thr protein kinase family
  • NIMA subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • only NEK6 obviously localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis
  • localizes to different microtubule-based structures in mitosis
  • NEK6 and NEK7 are enriched in the centrosome
  • basic FUNCTION
  • mitotic histone kinase regulatring chromatin condensation
  • having important function during mitosis and NEK6 kinase is required for metaphase-anaphase transition
  • play important roles at the G2-M transition in nuclear envelope breakdown and centromere separation
  • novel target of the DNA damage checkpoint and the inhibition of its activity is required for proper cell cycle arrest in the G(2)/M phase upon DNA damage
  • contribute to mitotic progression downstream of another NIMA-related kinase, NEK9
  • play independent roles not only in robust mitotic spindle formation but also potentially in cytokinesis
  • with NEK7 are required for robust mitotic spindle formation and cytokinesis
  • emerge as factor that function at multiple steps of progression through mitosis, as NEK6 and NEK7 have previously been shown to also support mitotic spindle formation and cytokinesis
  • NEK6 and NEK7 might be required for timely nuclear envelope permeabilization during mitotic entry
  • NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    with NEK9 and NEK7 are components of a mitotic spindle-signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with APBB1 (NEK6 binds to APBB1 through its (267)PPLP(270) motif and the protein-protein interaction between NEK6 and APBB1 regulates their subcellular localization and cell apoptosis)
  • combined action of CDK1, NEK6, NEK7, and likely other kinases contributes to hyperphosphorylation of NUP98 during mitosis
  • TPP1 interacts with the cell cycle regulator kinase NEK6 in human cells, and NEK6-mediated phosphorylation of TPP1 Ser255 in G2/M phase regulates the association between telomerase activity and TPP1
  • cell & other
    REGULATION
    activated by NEK9 (cascade of mitotic NIMA family protein kinases whose combined function is important for mitotic progression)
    Other phosphorylated by NEK9 at S206 within its activation loop
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    of NEK7 or its close paralog, NEK6, has previously been shown to arrest cells in mitosis, mainly at metaphase
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS