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FLASH GENE
Symbol AK1 contributors: npt/ - updated : 24-10-2006
HGNC name adenylate kinase 1
HGNC id 361
Corresponding disease
AK1 hemolytic anemia
Location 9q34.11      Physical location : 130.628.760 - 130.640.022
Synonym name
  • myokinase
  • ATP-AMP transphosphorylase
  • adenylate kinase isoenzyme 1
    • EC.number 2.7.4.3
    DNA
    TYPE functioning gene
    STRUCTURE 11.26 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    text two alternative transcripts 2.5, 0.9 kb differing by 3'utr
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2266 51.5 194 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver    
    Endocrinepancreas   highly
     thyroid    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    Blood/Hematopoieticplatelet
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • adenylate and thymidylate kinase domain
    • HOMOLOGY
    interspecies homolog to murine Ak1
    Homologene
    FAMILY
  • adenylate kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • adenylate kinase 1 responsible of the phosphorylation of AMP in RBC and production of ADP
  • implicated in adenine nucleotide catabolic pathway and guanine nucleotide pools homeostasis
  • regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AK1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS