| basic FUNCTION
| proliferation associated antigen (marker of breast carcinoma), playing an important role in implantation and development of placenta |
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involved in cardiovascular development but also in vascular homeostasis |
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proliferation-associated and hypoxia-inducible protein expressed in endothelial cells  |
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may playing a critical role in the binding of |
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endothelial cells to integrins and/or other RGD receptors |
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might undergo conformational adaptations upon TGF-beta binding |
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plays distinct and cell-autonomous roles invascular smooth muscle cell recruitment and arteriovenous specification via NR2F2 in angiogenesis that may contribute to ORW1 |
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important role of endoglin in tumor cell plasticity and progression of aggressive tumors |
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essential for angiogenesis/vascular development and a co-receptor of TGFbeta |
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can suppress cell movement out of primary tumor as well as the formation of distant metastasis |
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endothelial-specific transforming growth factor beta (TGFB1) coreceptor essential for angiogenesis and vascular homeostasis |
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modulates the hematopoietic transcriptional network, most likely through regulation of BMP4 signaling |
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endothelial ENG interacts with leukocyte ITGA5B1 via its RGD motif, and this adhesion process is stimulated by the inflammatory chemokine CXCL12, suggesting a regulatory role for endoglin in transendothelial leukocyte trafficking |
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auxiliary receptor for transforming growth factor-beta (TGFB1), with important roles in vascular function |
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importance of ENG in both canonical and non-canonical TGFB1 signaling pathways modulating both the activation and quiescence of the endothelium during angiogenesis |
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ENG and and ACVRL1 contribute to several novel networks, including TGFB1 dependent and independent ones, critical for vascular function and potentially defective in hereditary hemorrhagic telangiectasia |
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has a critical function in the development of the vascular system |
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is required for efficient VEGFA-induced angiogenesis |
