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FLASH GENE

Symbol

FPGS

contributors: KTN/npt - updated : 04/12/2008

HGNC name	folylpolyglutamate synthase
HGNC id	3824

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q34.11      Physical location : 130.565.153 - 130.576.556
Synonym name	gat-minus auxotroph
	tetrahydrofolylpolyglutamate synthase
	folylpoly-gamma-glutamate synthetase
Synonym symbol(s)	GMA
EC.number	6.3.2.17

DNA

TYPE	functioning gene
STRUCTURE	11.40 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 15 splicing 2487 - 587 - Leclerc, 2001 Turner, 2000 a 42 aa transit peptide of 4.5 kda acting as a mitochondrial targeting sequence a 545 aa mature peptide of 60.2 kda having two alternative translational start codons in the same reading frame which encode either a longer, signal-containing mitochondrial protein or a shorter, signal-less cytosolic protein variant 2 15 splicing 2475 59 537 . encoding a cytosolic protein Leclerc, 2001 Turner, 2000 using an alternate exon for its 5' UTR compared to variant 1 using a downstream start codon compared to variant 1

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately Lymphoid/Immune lymph node       moderately   thymus       moderately Reproductive female system uterus cervix   highly   female system ovary     moderately   male system prostate     moderately Skin/Tegument skin       moderately

cell lineage
cell lines
fluid/secretion	predominantly in lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an N terminal 42 AA mitochondrial leader peptide

mono polymer

monomer

HOMOLOGY

interspecies	homolog to dog FPGS (86.9 pc)
	homolog to murine Fpgs (81.9 pc)

Homologene

FAMILY

folylpolyglutamate synthase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,cytosolic

basic FUNCTION

involved in the conversion of folates to polyglutamate derivatives

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

cofactor

signaling

tetrahydrofolylpolyglutamate biosynthesis

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS