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FLASH GENE
Symbol FPGS contributors: KTN/npt - updated : 04/12/2008
HGNC name folylpolyglutamate synthase
HGNC id 3824
Location 9q34.11      Physical location : 130.565.153 - 130.576.556
Synonym name
  • gat-minus auxotroph
  • tetrahydrofolylpolyglutamate synthase
  • folylpoly-gamma-glutamate synthetase
    • Synonym symbol(s) GMA
    EC.number 6.3.2.17
    DNA
    TYPE functioning gene
    STRUCTURE 11.40 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 splicing 2487 - 587 - Leclerc, 2001 Turner, 2000
  • a 42 aa transit peptide of 4.5 kda acting as a mitochondrial targeting sequence
  • a 545 aa mature peptide of 60.2 kda
  • having two alternative translational start codons in the same reading frame which encode either a longer, signal-containing mitochondrial protein or a shorter, signal-less cytosolic protein
    • 15 splicing 2475 59 537 . encoding a cytosolic protein Leclerc, 2001 Turner, 2000
  • using an alternate exon for its 5' UTR compared to variant 1
  • using a downstream start codon compared to variant 1
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Lymphoid/Immunelymph node   moderately
     thymus   moderately
    Reproductivefemale systemuteruscervix highly
     female systemovary  moderately
     male systemprostate  moderately
    Skin/Tegumentskin   moderately
    cell lineage
    cell lines
    fluid/secretion predominantly in lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal 42 AA mitochondrial leader peptide
    • mono polymer monomer
    HOMOLOGY
    interspecies homolog to dog FPGS (86.9 pc)
    homolog to murine Fpgs (81.9 pc)
    Homologene
    FAMILY
  • folylpolyglutamate synthase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the conversion of folates to polyglutamate derivatives
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor
    signaling
    tetrahydrofolylpolyglutamate biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS