| basic FUNCTION
| able to generate the RNA primers required by DNA polymerase G, to initiate replication of mtDNA |
|
playing a roles in early development and postnatal cell injury |
|
promoting cell death of non-invasive breast cancer cells |
|
mitochondrion-specific nuclease that translocates to the nucleus during apoptosis |
|
cleaves chromatin DNA into nucleosomal fragments independently of caspases |
|
represents a caspase-independent apoptotic pathway initiated from the mitochondria |
|
mitochondrial enzyme, known to be involved in caspase-independent cell death following translocation to the cellular nucleus  |
|
important role of ENDOG in the senescence program of human endothelial cells |
|
role for ENDOG in the generation of S region DSBs and class switch DNA recombination (CSR) |
|
role for ENDOG in maladaptive cardiac hypertrophy |
|
ENDOG and TOP2A may actively participate in apoptotic chromatin degradation |
|
largely related with a role in the modulation of a caspase-independent cell death pathway in many cellular systems |
|
could play a highly specific role in the regulation of anxiety by modulating synaptic components |
|
is a mitochondrially localized nuclease that triggers DNA degradation and cell death upon translocation from mitochondria to the nucleus |
|
ENDOG is a critical downstream executor of SNCA cytotoxicity |
|
is responsible for DNA fragmentation both during and after cell death |
