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Symbol DAPK1 contributors: mct/pgu - updated : 15-11-2019
HGNC name death-associated protein kinase 1
HGNC id 2674
Location 9q21.33      Physical location : 90.112.755 - 90.323.548
Synonym name DAP kinase 1
Synonym symbol(s) DAPK, DAPK-1, DKFZp781I035
TYPE functioning gene
STRUCTURE 210.80 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
MAPPING cloned Y linked N status provisional
Physical map
LOC389766 9 similar to RIKEN cDNA 4921517D22 HBLD2 9q22.1 HESB like domain containing 2 ZCCHC6 9q21 zinc finger, CCHC domain containing 6 LOC392358 9 similar to 40S ribosomal protein S6 (Phosphoprotein NP33) GAS1 9q21.3-q22.1 growth arrest-specific 1 LOC157956 9q22.1 cell division cycle 20 pseudogene LOC392359 9 similar to transactivator HSM-1 DAPK1 9q34.1 death-associated protein kinase 1 CTSL 9q21-q22 cathepsin L LOC392360 9 similar to Eukaryotic translation initiation factor 3 subunit 1 (eIF-3 alpha) (eIF3 p35) (eIF3j) LOC392361 9 similar to Cathepsin L precursor (Major excreted protein) (MEP) LOC392362 9 similar to fructose-1,6-bisphosphatase 2; fructose-1,6-bisphosphatase isozyme 2; D-fructose-1,6-bisphosphate 1-phosphohydrolase; FBPase; muscle fructose-bisphosphatase; hexosediphosphatase LOC392363 9 similar to Cathepsin L precursor (Major excreted protein) (MEP) LOC392364 9 similar to chromosome 15 open reading frame 2 FLJ35866 LOC286235 9q22.2 hypothetical protein LOC286235 CCRK 9q22.2 cell cycle related kinase LOC158104 9q22.2 similar to 40S ribosomal protein S10 LOC389767 9 LOC389767 DKFZP434M131 9q22.1 DKFZP434M131 protein LOC389768 9 similar to potassium channel tetramerisation domain containing 1; chromosome 18 open reading frame 5 LOC389769 9 similar to Laminin receptor 1 SPIN 9q22.1-q22.3 spindlin LOC158046 9q22.2 similar to hypothetical protein BC014127
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 5942 - 1430 - 2001 11579085
Type widely
constitutive of
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunethymus   highly
Reproductivefemale systemplacenta  highly
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
  • a N terminal protein-kinase domain followed by a conserved calmodulin binding domain
  • eight ankyrin repeats
  • two P-loops
  • a death domain
  • a functional ROC (Ras of complex proteins) domain that mediates homo-oligomerization and GTP binding through a defined P-loop motif (GTP binding regulates its function through intramolecular signalling)
  • protein kinase superfamily
  • serine/threonine protein kinase family
  • ROCO family of proteins
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • adhesion inhibitory effect, inducing death coupling the control of apoptosis to metastasis
  • calcium/calmodulin serine/threonine kinase, which positively mediates programmed cell death in a variety of systems
  • involved in Fas-induced extrinsic apoptosis in lymphoid cells
  • phosphorylates BECN1 on Thr 119 located at a crucial position within its BH3 domain, and thus promotes the dissociation of BECN1 from BCL2L1 and the induction of autophagy
  • phosphorylates tropomyosin-1 in response to ERK activation by hydrogen peroxide (H(2)O(2), and regulates the formation of stress fibers in response to oxidative stress
  • modulation of DAPK1 activities is critical for regulation of apoptosis and cellular homeostasis
  • phosphorylating GRIN2B and in turn enhancing the NR1/NR2B receptor channel conductance
  • promotes cell death partly through its effect on regulating actin cytoskeletons (
  • molecular link of DAPK to tau phosphorylation, an event associated with Alzheimer disease pathology
  • inhibits the ability of PIN1 to induce centrosome amplification and cell transformation
  • calmodulin-dependent protein kinases that are regulated by oligomerization, calmodulin binding, and autophosphorylation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    a component
  • constituent of the actin microfilament network
    small molecule
  • suppressing integrin activity and disrupting matrix survival signals thereby activating a p53 dependent apoptotic pathway
  • interaction with GRIN2B mediating brain damage in stroke
  • KLHL20-CUL3-RBX1 E3 ligase complex promotes DAPK1 polyubiquitination, thereby inducing the proteasomal degradation of DAPK1, and controling interferon response
  • interacting with PIN1 (phosphorylates PIN1 and inhibits its prolyl isomerase activity and cellular function)
  • interacting with UNC5B (triggers cell death through the activation of the serine-threonine protein kinase DAPK1)
  • ATF6 in association with the transcription factor CEBPB, regulates IFNG-induced expression of DAPK1
  • ITPRIP binds directly to DAPK1 and inhibits DAPK1 catalytic activity
  • cell & other
    repressed by HOXB7
    Other calcium Ca2+/calmodulin-regulated
    triggered by IFNG
    regulated by CEBPB (CEBPB binds to the promoter of DAPK1 and is required for the regulation of DAPK1)
    regulated by RGM/neogenin that regulates cell fate by controlling the DAPK1 activity
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    by hypermethylation in head and neck carcinomas
    tumoral     --low  
    by promoter methylation in B cell chronic lymphocytic leukemia and chronic myeloid leukemia (promoter methylation might play a significant role in the progression of CML)
  • to late-onset Alzheimer's disease
  • to chronic lymphocytic leukemia
  • Variant & Polymorphism SNP
  • significantly associated with late-onset Alzheimer's disease
  • downregulation in familial chronic lymphocytic leukemia
  • Candidate gene for sensitive detection in plasma or serum of cancer gastric, lung cancer, head and neck cancer, by DNA methylation markers
    Therapy target
    for the development of novel treatment regimens in chronic lymphocytic leukemia involving epigenetic therapies for gene reactivation