basic FUNCTION
| heparin binding growth factor |
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functioning as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor and mitogen for a variety of mesoderm- and neuroectoderm cells |
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involved in organogenesis, in cardiomyocyte proliferation and angiogenesis during development |
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perichondrial FGF1, FGF2, FGF6, FGF7, FGF9, FGF18, FGF21, fGF22 regulate growth plate chondrogenesis  |
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potent inducer of cell migration and chemotaxis |
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activates spinal astrocytes, and activated astrocytes are implicated in neurodegenerative disorders such as amyotrophic lateral sclerosis  |
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involved in opening pannexin and connexin hemichannels  |
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stress-induced unconventional export of FGF1, is associated with and dependent on the formation of membrane blebs and localized cell surface exposure of phosphatidylserine  |
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metabolic role for FGF1 as a critical transducer of PPARG signalling that mediates the proper coupling of nutrient storage to adaptive remodelling of adipose tissue  |
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FGF1 and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels  |
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induces maturation and cell cycle exit in chondrocytes, triggers rapid accumulation of RBL1-PPP2R2A complexes coinciding with RBL1 dephosphorylation  |
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prolonged biological activity of FGF1 can be achieved by increasing its proteolytic resistance directly linked to improved global thermostability  |
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acts through cell surface tyrosine kinase receptors, but FGF1 can also act directly in the cell nucleus, as a result of nuclear import of endogenously produced, non-secreted FGF1 or by transport of extracellular FGF1 via endosomes and cytosol into the nucleus  |
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antidiabetes function of FGF1 may act partially through increasing beta-cell differentiation  |
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role of intracellular FGF1 is to protect the cell against stress conditions by providing an additional signal for cell survival, independently of receptor-activated signaling cascades  |
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lacking a secretion peptide signal and acting mainly in an intracellular and nuclear manner  |