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FLASH GENE
Symbol PFDN1 contributors: npt/ - updated : 08-03-2008
HGNC name prefoldin subunit 1
HGNC id 8866
Location 5q31.3      Physical location : 139.624.634 - 139.682.689
Synonym name prefoldin 1
Synonym symbol(s) PDF, PFD1
DNA
TYPE functioning gene
STRUCTURE 58.05 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DKFZp761B0514 5q31.3 hypothetical protein DKFZp761B0514 NRG2 5q23-q33 neuregulin 2 PURA 5q31 purine-rich element binding protein A ORF1-FL49 5q31.3 putative nuclear protein ORF1-FL49 PFDN1 5q31-q32 prefoldin 1 DTR 5q23-q31 diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) SLC4A9 5q31 solute carrier family 4, sodium bicarbonate cotransporter, member 9 FLJ20288 SLC35A4 5q31.3 solute carrier family 35, member A4 EIF4EBP3 5q31.3 eukaryotic translation initiation factor 4E binding protein 3 SRA1 5q31.3 steroid receptor RNA activator 1 APBB3 5q31 amyloid beta (A4) precursor protein-binding, family B, member 3 CD14 5q31.1 CD14 antigen PRO1580 5q31.3 hypothetical protein PRO1580
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1324 14.08 122 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , hexamer
HOMOLOGY
interspecies homolog to C.elegans C08F8.1
intraspecies homolog to keratin
Homologene
FAMILY
  • prefolding beta subunit family
  • CATEGORY chaperone/stress , structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • assisting in the correct folding of other proteins
  • transfering target proteins to cytosolic chaperonin (C-CPN)(Vainberg 1998)
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathway for nonnative proteins
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • heterohexamer of two PFD-alpha type and four PFD-beta type subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to cytosolic chaperonin (C-CPN)
  • binding to nascent polypeptide chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS