Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD14 contributors: shn/mct - updated : 16-04-2011
HGNC name CD14 molecule
HGNC id 1628
Location 5q31.3      Physical location : 140.011.312 - 140.013.286
Synonym name
  • CD14 antigen
  • monocyte differentiation antigen CD14
  • myeloid cell-specific leucine-rich glycoprotein
  • DNA
    TYPE functioning gene
    STRUCTURE 1.97 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site
    text structure
  • SP1 binding site, CCAT/enhancer binding site
  • regulation of CD14 promoter by LGR4 is mediated by the PKA-CREB pathway
  • MAPPING cloned Y linked   status confirmed
    Map cen -D5S2009 - D5S2116 - CD14 - D5S2119 - D5S2119 - qter
    Physical map
    FLJ20288 SLC35A4 5q31.3 solute carrier family 35, member A4 EIF4EBP3 5q31.3 eukaryotic translation initiation factor 4E binding protein 3 SRA1 5q31.3 steroid receptor RNA activator 1 APBB3 5q31 amyloid beta (A4) precursor protein-binding, family B, member 3 CD14 5q31.1 CD14 antigen PRO1580 5q31.3 hypothetical protein PRO1580 NDUFA2 5q31.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa IK 2p15-p14 IK cytokine, down-regulator of HLA II FLJ20195 5q31.3 hypothetical protein FLJ20195 DND1 5q31.3 dead end homolog 1 (zebrafish) HARS 5q31.1 histidyl-tRNA synthetase HARSL 5q31.1-q33.2 histidyl-tRNA synthetase-like FLJ31121 5q31.3 hypothetical protein FLJ31121 PCDHA1 5q31.3 protocadherin alpha 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 splicing 1648 55 375 - 2013 23589304
    1 splicing 1561 55 375 - 2013 23589304
    1 splicing 1661 55 375 - 2013 23589304
    1 splicing 1540 55 375 - 2013 23589304
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousgangliasensory gangliadorsal root  
     nerve   highly
     spinal cord    
    Reproductivefemale systemovary  highly
     female systemplacenta  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialbarrier liningendothelium   Homo sapiens
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Blood/Hematopoieticmonocyte
    Cardiovascularendothelial cell Homo sapiens
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 11 leucine rich repeats
  • a region spanning amino acids 57-64 critical for interacting with TLR2 and enhancing TLR2-mediated peptidoglycan signaling
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Cd14, Mus musculus
    ortholog to Cd14, Rattus norvegicus
    Homologene
    FAMILY
    CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • functional receptor for peptidoglycan
  • receptor for bacterial liposaccharides, recruiting LPS to TLR proteins and inducing a liposaccharide signaling pathway
  • involved in the clearance of apoptotic cells
  • regulator of IgE levels
  • enhancing Toll-like receptor 2 (TLR2)-mediated signaling in response to peptidoglycan
  • plays a major role in the inflammatory response of monocytes to lipopolysaccharide (LPS)
  • plays a very important role in transferring LPS from LPS-binding protein to TLR4, which was regarded as the initiation of TLR4 signaling
  • critical regulator of the microglial inflammatory response that acts to modulate betta-amyloid deposition
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text innate immunity
    PATHWAY
    metabolism
    signaling signal transduction
    MAP kinase and NF-kappa B pathway
    a component component of a complex with TLR4 and LY96 binding LPS and trafficking to Golgi apparatus to plasma membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Mac-2-binding protein, Mac-2-BP
  • Toll-like receptor 2, TLR2
  • lactoferrin, LTF
  • ceramide, CD55, Fcgamma-receptors CD32, CD64 and the pentaspan CD47
  • lipopolysaccharide, LPS and lipopolysaccharide binding protein, LBP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • severe chronic periodontitis
  • to Crohn disease (in association with CARD15)
  • to IgA nephropathy in progression
  • Variant & Polymorphism
  • 159 TT allele and1359G:/T increases this risk of Crohn disease
  • T159C associated to IgA nephropathy in progression
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • CD14-deficient miceare highly resistant to shock induced by either live Gram-negative bacteria or LPS and show dramatically reduced levels of bacteremia
  • Bone marrow-derived macrophages (BMDMs) from CD14-/- mice exhibited impaired responses to polyinosine-polycytidylic acid (pIpC) and reduced production of inflammatory cytokines
  • mice lacking CD14 exhibited reduced insoluble, but not soluble, levels of betta-amyloid at 7 months of age and have a significant change in the inflammatory environment of the brain