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FLASH GENE
Symbol HBEGF contributors: mct - updated : 28-04-2016
HGNC name heparin-binding EGF-like growth factor
HGNC id 3059
Location 5q31.3      Physical location : 139.712.428 - 139.726.188
Synonym name
  • diphtheria toxin receptor
  • heparin-binding epidermal growth factor-like growth factor
  • proheparin-binding EGF-like growth factor
    • Synonym symbol(s) DTS, HEGFL, HBGF, DTR, DTSF
    DNA
    TYPE functioning gene
    STRUCTURE 13.76 kb     6 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2381 - 208 - 2008 17928891
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text villous and extra-villous cytotrophoblast cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one EGF-like domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Hbegf
    ortholog to rattus dtr
    Homologene
    FAMILY
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in macrophage-mediated cellular proliferation
  • mitogenic for fibroblasts and smooth muscle but not endothelial cells
  • with PTGS2 and ST6GALNAC5, are mediators of cancer cell passage through the blood-brain barrier
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EGR4 (mediates EGFR signaling pathway through HBEGF)
  • HAS3 is induced by HBEGF and seems mainly involved in atopic dermatitis (AD) epidermis
  • SOX2 mediates the expression of HBEGF and FSCN1 by activating AKT1 and CTNNB1 signaling pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in preeclampsia and in fetal growth retardation
    constitutional     --low  
    in smooth muscle or endothelial cell lineages causes heart malformation
    tumoral     --over  
    in ovarian, gastric, and breast cancer, melanoma and glioblastoma cells
    Susceptibility to dyphteria toxin
    Variant & Polymorphism
    Candidate gene marker of the keratinocyte's response to a challenging environment and this growth factor alters the phenotype of keratinocytes in a manner similar to that observed during epidermal repair
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    cancer therapy
    ANIMAL & CELL MODELS