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FLASH GENE

Symbol

HBEGF

contributors: mct - updated : 28-04-2016

HGNC name	heparin-binding EGF-like growth factor
HGNC id	3059

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q31.3      Physical location : 139.712.428 - 139.726.188
Synonym name	diphtheria toxin receptor
	heparin-binding epidermal growth factor-like growth factor
	proheparin-binding EGF-like growth factor
Synonym symbol(s)	DTS, HEGFL, HBGF, DTR, DTSF

DNA

TYPE	functioning gene
STRUCTURE	13.76 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001945 6 - 2381 NP_001936 - 208 - 2008 17928891

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine pancreas       highly Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	villous and extra-villous cytotrophoblast cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one EGF-like domain

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Hbegf
	ortholog to rattus dtr

Homologene

FAMILY

CATEGORY

signaling , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	involved in macrophage-mediated cellular proliferation
	mitogenic for fibroblasts and smooth muscle but not endothelial cells
	with PTGS2 and ST6GALNAC5, are mediators of cancer cell passage through the blood-brain barrier

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	muscle development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with EGR4 (mediates EGFR signaling pathway through HBEGF)
	HAS3 is induced by HBEGF and seems mainly involved in atopic dermatitis (AD) epidermis
	SOX2 mediates the expression of HBEGF and FSCN1 by activating AKT1 and CTNNB1 signaling pathways

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in preeclampsia and in fetal growth retardation constitutional     --low   in smooth muscle or endothelial cell lineages causes heart malformation tumoral     --over   in ovarian, gastric, and breast cancer, melanoma and glioblastoma cells

Susceptibility

to dyphteria toxin

Variant & Polymorphism

Candidate gene	marker of the keratinocyte's response to a challenging environment and this growth factor alters the phenotype of keratinocytes in a manner similar to that observed during epidermal repair
Marker
Therapy target
	System Type Disorder Pubmed cancer     cancer therapy

ANIMAL & CELL MODELS