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FLASH GENE
Symbol TAF7 contributors: mct - updated : 30-06-2013
HGNC name TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
HGNC id 11541
Location 5q31.3      Physical location : 140.698.057 - 140.700.351
Synonym name
  • RNA polymerase II TBP-associated factor
  • Synonym symbol(s) TAF2F, TAFII55
    DNA
    TYPE functioning gene
    STRUCTURE 2.29 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PCDHB10 5q31.3 protocadherin beta 10 PCDHB11 5q31.3 protocadherin beta 11 PCDHB12 5q31.3 protocadherin beta 12 PCDHB13 5q31.3 protocadherin beta 13 PCDHB14 5q31.3 protocadherin beta 14 PCDHB18 5q31.3 protocadherin beta 18 pseudogene PCDHB19P 5q31 protocadherin beta 19 pseudogene PCDHB15 5q31.3 protocadherin beta 15 SLC25A2 5q31 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member TAF7 5q31 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa PCDHGA1 5q31.3 protocadherin gamma subfamily A, 1 PCDHGA2 5q31.3 protocadherin gamma subfamily A, 2 PCDHGA3 5q31.3 protocadherin gamma subfamily A, 3 PCDHGB1 5q31.3 protocadherin gamma subfamily B, 1 PCDHGA4 5q31.3 protocadherin gamma subfamily A, 4 PCDHGB2 5q31.3 protocadherin gamma subfamily B, 2 PCDHGA5 5q31.3 protocadherin gamma subfamily A, 5 PCDHGB3 5q31.3 protocadherin gamma subfamily B, 3 PCDHGA6 5q31.3 protocadherin gamma subfamily A, 6 PCDHGA7 5q31.3 protocadherin gamma subfamily A, 7 PCDHGB4 5q31.3 protocadherin gamma subfamily B, 4 PCDHGA8 5q31.3 protocadherin gamma subfamily A, 8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2310 - 349 - 2010 20937824
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • JUN co-activator mediating activation of AP-1 target genes in response to extracellular signals
  • functions not only as one of the TAFs, but also a coactivator for JUN
  • physiological function of TAF7 as a basal regulator for mammalian polyamine transport activity and polyamine analog MGBG-induced apoptosis
  • role in regulating transcription initiation
  • functions as a check-point regulator suppressing premature transcription initiation until preinitiation complex assembly is complete
  • plays a critical role in regulating TFIID-dependent transcription initiation by preventing premature transcription initiation
  • contributes to the regulation of the transition from preinitiation complex assembly to initiation and elongation
  • regulates transcription initiation of TAF1-dependent genes by binding to the acetyltransferase (AT) domain of TAF1 and inhibiting the enzymatic activity that is essential for transcription
  • role of TAF7 extending beyond canonical TFIID-dependent transcription because it also plays a critical role in regulating CIITA-dependent transcription
  • is likely essential for proliferation but not for proliferation-independent differentiation
  • novel roles for the TAF1-TAF7 complex in regulation of PIC assembly via reading epigenetic histone marks
  • TAF1 and TAF7, two subunits of TFIID, are integral to the regulation of eukaryotic transcription initiation and play key roles in preinitiation complex (PIC) assembly
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TFIID component
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • interacts with TAFII230, the largest subunit of TFIID, and with multiple transcription activators, including Sp1,YY1, USF, CTF
  • binds to TAF1 and inhibits its intrinsic acetyl transferase activity
  • interacts with JUN through two independent interaction domains, within the N- and C-terminal part of JUN
  • interacts with the transcription factors, GT2H4 and CDK9
  • binds to CIITA and inhibits its AT (acetyltransferase) activity, thereby repressing activated transcription
  • interacts with and regulates the enzymatic activities of other transcription factors, including CDK9, GTF2H1, and CIITA, ensuring an orderly progression in transcription initiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS