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FLASH GENE

Symbol

TBC1D25

contributors: mct - updated : 25-10-2011

HGNC name	TBC1 domain family, member 25
HGNC id	8092

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	22.92 kb     6 Exon(s)

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	pter - DXS228 - DXS7 - UBE1 - DXS1055 - DXS1003 - DXS1146 - DXS1266 - ARAF ,SYN1 ,TIMP1 - PFC - (DXS426 ,ELK1 ),ZNF41 - ZNF81 - DXS6849 - ZNF21 - DXS1265 - DXS1267 - (TBC1D25 ,DXS6950 - DXS6949 ) - DXS722 - WAS ,DXS1011E ,DXS7467 - DXS1358 - GATA1 - DXS226 - ERAS - DXS1126 - DXS1240 - DXS1011E ,DXS1470 - TFE3 - DXS576 ,LMO6 - SYP - DXS573 - DXS1039 - DXS255 - CLCN5 - DXS146 - OATL2 - DXS14 - cen
Authors	Knight (92), Berger (92), Coleman (93), Knight (94), Coleman (94), Consensus, Willard (94), Boycott (96), Fisher (97)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2227 - 100 - Chand NM_002536 6 - 3830 76.3 688 - 2009 19077034

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           salivary gland       highly Hearing/Equilibrium ear inner cochlea     Reproductive male system prostate

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a TBC domain

HOMOLOGY

interspecies

ortholog to murine Oatl1

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

basic FUNCTION	functioning as a Rab GTPase activating protein
	recruited to isolation membranes and autophagosomes through direct interaction with GABARAPL2 homologues and is involved in the fusion between autophagosomes and lysosomes through its GAP activity
	involved in the fusion between autophagosomes and lysosomes through its GAP activity and its GABARAPL2 homolog binding activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

RAB33B is a target substrate of TBC1D25 and is involved in the fusion between autophagosomes and lysosomes, the same as TBC1D25

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS