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FLASH GENE
Symbol ARAF contributors: - updated : 29-10-2005
HGNC name v-raf murine sarcoma 3611 viral oncogene homolog 1
HGNC id 646
Location Xp11.4-p11.2      Physical location : 47.420.515 - 47.431.319
Synonym symbol(s) PKS2, A-RAF, RAFA1, ARAF1
EC.number 2.7.1.-
DNA
TYPE functioning gene
STRUCTURE 10.00 kb     16 Exon(s)
MAPPING cloned Y linked Y status confirmed
Map see SYN1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Reproductivefemale systembreastmammary gland highly
 female systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phorbol-ester/DAG-type zinc finger
  • a RBD (Ras-binding) domain
    • HOMOLOGY
    interspecies homolog to murine sarcoma 3611 viral (v-raf) oncogene A1
    Homologene
    FAMILY Ser/Thr protein kinase family, RAF subfamily
    CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION involved in the transduction of mitogenic signals from the cell membrane to the nucleus
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 2 zinc ions per subunit
    protein interacting with TH1L
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS