| basic FUNCTION
| putatively involved in actin polymerization, cytoskeleton rearrangement and lymphoid signaling in response to external stimuli transmitted by tyrosine kinase receptors and small GTPases |
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playing a role in cell organization |
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controlling in cooperation with CDC42, the podosomes (dynamic actin-containing adhesion structures of primary human macrophage and involved in migratory processes) |
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playing a unique role for peripheral T cell function, but T cell development depends on the combined activity of WAS and WASL |
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involved in signaling and cytoskeletal organization that includes WAS and Scar/WASP-family verprolin homologous (WAVE) proteins (Le Bras 2009) |
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plays a critical role in cellular function by linking surface receptor signaling to actin reorganization (Le Bras 2009) |
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cytoskeletal regulator in hematopoietic cells (Blundell 2009) |
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crucial role in filopodia formation  |
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cytoskeletal remodeling mediated by WAS in dendritic cells is necessary for normal immune synapse formation and T-cell priming |
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controls CD4(+) T-cell motility upon antigen-presenting cells (APC) encounter by regulating lymphocyte function-associated antigen 1 spatial distribution |
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WAS and WIPF1 localise to the actin rich core of podosomes and play a critical role in their formation |
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regulates actin polymerization in nucleated hematopoietic cells but has other role(s) in platelets |
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WAS function restricts TGFB1 secretion in a CDC42- and SRC family kinase-dependent manner and independently of actin assembly |
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novel role for PSTPIP1 and WAS in orchestrating different |
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types of actin-based protrusions |
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WAS and WASF2 differ in their dynamics and their associated proteins |
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WAS and WASF1 may both be required to build pseudopods |
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WAS is crucial for pseudopod formation of neutrophils |
