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FLASH GENE
Symbol ZNF41 contributors: mct - updated : 09-10-2017
HGNC name zinc finger protein 41
HGNC id 13107
Corresponding disease
MRX89 mental retardation, 89
Location Xp11.3      Physical location : 47.305.561 - 47.342.345
Synonym symbol(s) MRX89
DNA
TYPE functioning gene
STRUCTURE 38.98 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see ZNF157
Physical map
SLC9A7 Xp11.4-p11.1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 7 RP2 Xp11.23 retinitis pigmentosa 2 (X-linked recessive) PHF16 Xp11.3-p11.23 PHD finger protein 16 RGN Xp11.3-q11.2 regucalcin (senescence marker protein-30) RNU12 Xp11.3 RNA, U12 small nuclear P17.3 Xp11.3 neuronal protein 17.3 RBM10 Xp11.23 RNA binding motif protein 10 UBE1 Xp11.23 ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) INE1 Xp11.4-p11.3 inactivation escape 1 PCTK1 Xp11.3 PCTAIRE protein kinase 1 USP11 Xp21.2-p11.2 ubiquitin specific protease 11 ZNF157 Xp11.23 zinc finger protein 157 (HZF22) ZNF41 Xp11.23 zinc finger protein 41 LOC389850 X similar to hypothetical protein, MGC:7199 TIMP1 Xp11.23 tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) ARAF1 Xp11.3-p11.23 v-raf murine sarcoma 3611 viral oncogene homolog 1 SYN1 Xp11.23 synapsin I PFC Xp11.3-p11.23 properdin P factor, complement ELK1 Xp11.3-p11.23 ELK1, member of ETS oncogene family UXT Xp11.23-p11.22 ubiquitously-expressed transcript LOC392458 X similar to spermine synthase; spermidine aminopropyltransferase LOC392459 X similar to CpG binding protein (Protein containing PHD finger and CXXC domain 1) LOC286404 Xp11.3 hypothetical gene supported by NM_006990; AB026542 LOC389851 X similar to Itchy homolog E3 ubiquitin protein ligase (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1) LOC347344 Xp11.3 similar to Zinc finger protein 81 (HFZ20) ZNF21 Xp11.23 zinc finger protein 21 (KOX 14) LOC389852 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) FLJ20573 Xp11.3-p11.1 hypothetical zinc finger protein FLJ20573 SSX6 Xp11.2 synovial sarcoma, X breakpoint 6 psiSSX2 Xp11.2 SSX2 pseudogene LOC389853 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) LOC392460 X similar to Ornithine aminotransferase, mitochondrial precursor (Ornithine--oxo-acid aminotransferase) psiSSX3 Xp11.2 SSX3 pseudogene SSX5 Xp11.2-p11.1 synovial sarcoma, X breakpoint 5
RNA
TRANSCRIPTS type messenger
text several transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5359 89 779 - 1999 10449920
5 splicing 5232 89 779 - 1999 10449920
different 5'UTR
4 - 4666 - 693 - 1999 10449920
4 - 4695 - 693 - 1999 10449920
5 - 4956 89 779 - 1999 10449920
5 - 5017 89 779 - 1999 10449920
5 - 5046 - 779 - 1999 10449920
6 - 5144 89 779 - 1999 10449920
6 - 5132 - 693 - 1999 10449920
4 - 4711 - 693 - 1999 10449920
5 - 4972 - 781 - 1999 10449920
5 - 5062 - 781 - 1999 10449920
4 - 4735 - 693 - 1999 10449920
5 - 4996 - 789 - 1999 10449920
5 - 5086 - 789 - 1999 10449920
4 - 5008 - 693 - 1999 10449920
4 - 4907 - 621 - 1999 10449920
4 - 4688 - 745 - 1999 10449920
4 - 4883 - 813 - 1999 10449920
4 - 4673 - 743 - 1999 10449920
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Skeletonaxialskullfacemaxilla 
Visualeyelens   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KRAB/FBP (Kruppel associated box) at the N terminus
  • a potent transcription repression motif and 18 zinc finger motifs, C2H2 type, Krüppel-like, tandemly arranged at the C terminus
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY zinc finger protein family, C2H2 type, Krüppel-like,KRAB subfamily
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in gene-specific transcriptional repression
  • may be playing a critical role for cognitive development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX89
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS