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FLASH GENE

Symbol

FYCO1

contributors: mct - updated : 15-01-2025

HGNC name	FYVE and coiled-coil domain containing 1
HGNC id	14673

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ARCC4 congenital cataract, autosomal recessive 4
Location	3p21.31      Physical location : 45.959.395 - 46.037.307
Synonym name	zinc finger FYVE domain-containing protein 7
Synonym symbol(s)	FLJ13335, ZFYVE7, MGC126517, MGC126519, RUFY3, CATC2, CTRCT18

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene, opposite orientation
text	including STRL33, within the fourteenth intron of the FYCO1 gene, with an antiparallel transcription orientation.
STRUCTURE	77.93 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D3S3582 - LARS2 - D3S2354 - LIMD1 - SACM1L - SLC6A20 - LZTFL1 - CCR9 - CXCR6 - FYCO1 - XCR1 - NRBF2P - FLI1P - CCR1 - CCR3 - UQCRC2P - CCR5 - CCR2 - CCRL2 - LTF - D3S32 - TMEM7 - LRRC2L - LUZPP1 - TDGF1 - cen
Authors	Kiss (02)

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024513 18 - 8518 NP_078789 - 1478 - 2022 36342046 NM_001386430 14 - 8030 NP_001373359 - 1278 - 2022 36342046 NM_001386426 17 - 8407 NP_001373355 - 1438 - 2022 36342046 NM_001386427 17 - 8370 NP_001373356 - 1430 - 2022 36342046 NM_001386423 18 - 8511 NP_001373352 - 1477 - 2022 36342046 NM_001386429 17 - 5629 NP_001373358 - 1426 - 2022 36342046 NM_001386425 18 - 5739 NP_001373354 - 1464 - 2022 36342046 NM_001386421 19 - 8598 NP_001373350 - 1478 - 2022 36342046 NM_001386424 17 - 7197 NP_001373353 - 1476 - 2022 36342046 NM_001386428 18 - 7143 NP_001373357 - 1430 - 2022 36342046 NM_001386422 18 - 8562 NP_001373351 - 1478 - 2022 36342046

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart       highly Endocrine parathyroid       highly Nervous brain         Reproductive female system uterus cervix   highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal RUN domain
	a 9-amino acid-long F-type LIR motif, and FYCO1 requires a functional LIR motif to facilitate efficient maturation of autophagosomes under basal conditions, whereas starvation-induced autophagy was unaffected
	a C terminal FYVE domain with two coiled-coid domain in-between

HOMOLOGY

Homologene

FAMILY	ezrin/radixin/moesin family
	PI(3)P-binding protein family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,cytoplasm,cytoskeleton,microtubule
text	colocalize to microtubules and found adjacent to Golgi, but primarily colocalize to autophagosomes

basic FUNCTION	promotes microtubule (MT) plus end-directed transport of autophagic vesicles
	functions as an adapter linking autophagosomes to microtubule plus end-directed molecular motors
	associated with the exterior of autophagosomes and mediating microtubule plus-end-directed vesicle transport
	involved in lens development and transparency
	Ribonucleoprotein (RNP) granule homeostasis is likely regulated by FYCO1-mediated autophagy
	component of the autophagic machinery, that is essential for adaptation to cardiac stress
	is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles
	protein that promotes microtubule plus end-directed transport of autophagic and endosomal vesicles as a molecular interaction partner of activated CASP8

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to both MAP1LC3A, PtdIns(3)P and RAB7A, and contains a domain responsible for microtubule plus end-dependent transport
	NINL enhanced the interaction between RAB7A and FYCO1, thus accelerated autophagic flux and the formation of autophagolysosome
	FYCO1 is a novel and specific CASP8 substrate

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARCC4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function results in a diminished autophagic flux, impaired organelle removal, and cataractogenesis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Fyco1-deficient mice subjected to starvation or pressure overload are unable to respond with induction of autophagy and develop impaired cardiac function