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FLASH GENE
Symbol CCR9 contributors: mct - updated : 12-07-2007
HGNC name chemokine (C-C motif) receptor 9
HGNC id 1610
Location 3p21.3      Physical location : 45.927.995 - 45.944.667
Synonym symbol(s) GPR9-6, GPR6966, GPR28, CDw199, GPR-9-6
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 16.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - CCR4 - D3S1768 - D3S1561 - CCR8 - CX3CR1 - D3S2354 - CCBP2 - CCR9 - CCR3 - CCR1 - XCR1 - CCR2 - CCR5 - D3S1078 - cen
Physical map
KIAA1143 3p21.32 KIAA1143 protein KNSL7 3p21.33 kinesin-like 7 MGC29956 3p21.32 hypothetical protein MGC29956 LOC391532 3 similar to peptidyl-Pro cis trans isomerase TGM4 3p22-p21.3 transglutaminase 4 (prostate) FLJ20209 3p21.32 hypothetical protein FLJ20209 ZDHHC3 3p21.32 zinc finger, DHHC domain containing 3 KIAA0116 3p21 Homo sapiens KIAA0116 protein (KIAA0116), mRNA. TNA 3p21.3 tetranectin (plasminogen binding protein) CDCP1 3p24.3-p22.1 tetranectin (plasminogen binding protein) RIS1 3p21.3 tetranectin (plasminogen binding protein) LARS2 3p21.3 leucyl-tRNA synthetase 2, mitochondrial LIMD1 3p21.3 LIM domains containing 1 SACM1L 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) XT3 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) LZTFL1 3p21.3 leucine zipper transcription factor-like 1 CCR9 3p21.3 chemokine (C-C motif) receptor 9 FYCO1 3p21.3 FYVE and coiled-coil domain containing 1 CXCR6 3p21.3 chemokine (C-X-C motif) receptor 6 XCR1 3p21.3-p21.1 chemokine (C motif) receptor 1 LOC391533 3 similar to Vascular endothelial growth factor receptor 1 precursor (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) CCR1 3p21.31 chemokine (C-C motif) receptor 1 CCR3 3p21.31 chemokine (C-C motif) receptor 3 LTF 3p21.31 lactotransferrin TMEM7 3p21.3 transmembrane protein 7 LRRC2 3p21.3 leucine-rich repeat-containing 2 TDGF1 3p21.31 teratocarcinoma-derived growth factor 1 FLJ36525 3p21.31 hypothetical protein LOC259173 TMIE 3p21 hypothetical protein LOC259173 TSP50 3p14-p12 testes-specific protease 50 TESSP5 3p21.31 testis serine protease 5 LOC391534 3 hypothetical gene supported by AK128390 TESSP2 3p21.31 testis serine protease 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2544 41.9 369 - Yu, 2000
  • 3 exons
  • - splicing 2462 40.6 357 - Yu, 2000
  • 2 exons
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunelymph node   lowly
     spleen   lowly
     thymus   specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Ccr9 (86.5 pc)
    homolog to murine Ccr9 (85.6 pc)
    Homologene
    FAMILY
  • G protein coupled receptor superfamily (family 1)
  • beta chemokine receptor family
  • CATEGORY immunity/defense , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a specific receptor for chemokine SCYA25/TECK
  • transducing subsequently a signal by increasing the intracellular calcium ions level
  • acting as a alternative coreceptor with CD4 for HIV-1 infection
  • acting as a rhodopsin-like receptor
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by TLR2 ligands that induce CCR9 and CCR10 expression by circulating B cells and increased chemotaxis to cognate chemokines CCL25 and CCL28
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS