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FLASH GENE

Symbol

SLC6A20

contributors: - updated : 06-12-2006

HGNC name	solute carrier family 6 (neurotransmitter transporter), member 20
HGNC id	30927

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.3      Physical location : 45.796.941 - 45.838.035
Synonym name	neurotransmitter transporter RB21A
	X transporter protein 3
	sodium/imino-acid transporter 1
Synonym symbol(s)	XT3, Xtrp3, SIT1

DNA

TYPE	functioning gene
STRUCTURE	41.00 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed XT3-I1 - splicing 5350 65.9 592 kidney Nash eleven transmembrane domains 5'UTR = 188 bp XT3-I2 - splicing 5240 - 555 kidney Nash eleven transmembrane domains

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Nervous meninges           nerve cranial nerve         plexus choroid         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

twelve potential TM domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Xtrp3
	homolog to Drosophila Cg10804

Homologene

FAMILY	member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family
	sodium neurotranmitter symporter family

CATEGORY

signaling neurotransmitter , transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	having neurotransmitter/sodium symporter activity
	involved in neurotransmitter transport
	acting as a Na+-dependent proline transporter

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	small molecule transport

PATHWAY

metabolism

signaling

neurotransmission

kidney-specific orphan transporter

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	target for investigation of hereditary forms of iminoaciduria
Marker
Therapy target

ANIMAL & CELL MODELS