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FLASH GENE

Symbol

LTF

contributors: mct - updated : 10-10-2017

HGNC name	lactotransferrin
HGNC id	6720

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.31      Physical location : 46.477.496 - 46.506.395
Synonym name	lactoferrin
Synonym symbol(s)	HLF2, GIG12, LF

DNA

TYPE	functioning gene
STRUCTURE	28.90 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002343 17 - 2390 80 710 - 1997 9122171

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly   salivary gland       highly Lymphoid/Immune spleen       moderately Nervous brain       lowly Reproductive female system breast mammary gland   highly Homo sapiens   male system prostate     highly Respiratory respiratory tract trachea     predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Homo sapiens

cell lineage
cell lines
fluid/secretion	blood
	present in milk and a variety of secretions derived from glandular epithelium cells, present at high concentrations

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two peptidase S60 domains

conjugated

GlycoP

mono polymer

monomer

HOMOLOGY

interspecies	homolog to rattus Ltf (62.39 pc)
	homolog to murine Ltf (71.06 pc)

Homologene

FAMILY

transferrin family of iron-binding proteins.

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
text	secondary granules

basic FUNCTION	iron binding transport proteins which can bind two atoms of ferric iron in association with the binding of an anion, usually bicarbonate
	playing a role in transcription of IL1B and regulating transcription of genes containing lactoferrin binding sites
	having antimicrobial activity which depends on the extracellular cation concentration
	upregulating KDR expression
	stimulating VEGFA-mediated endothelial cell proliferation and migration
	important protein component of the innate immune system that is broadly distributed within the body fluids
	major defense protein of innate immunity, and a novel maturation factor for dendritic cells
	contributes to the activation of both the innate and adaptive immune responses by promoting the recruitment of leukocytes and activation of dendritic cells
	having the ability to function as a negative regulator of granulocyte migration
	possible role for its oligomerization in different biological activities
	acting both as an iron-binding protein and inflammatory modulator
	induces moderate activation of TLR4-mediated innate immunity through its carbohydrate chains
	iron-binding protein present in mammalian secretions, playing important roles in cancer prevention by inducing apoptosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text

iron

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	IL1B
	LTF binds IGBP1 and promotes the acceleration of cellular apoptosis
	LTF increases the catalytic activity of CTSG at physiological concentration, with its highest enhancing capacity under acidic (pH 5.0) conditions, and broadens the substrate selectivity of CTSG
	LTF-mediated enhancement of CTSG activity might promote innate immunity during acute inflammation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the brain of patients with Alzheimer disease

Susceptibility

to dental caries

Variant & Polymorphism other	A/G (exon 2, Lys/Arg) polymorphism associated with susceptibility to dental caries

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS