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FLASH GENE
Symbol LTF contributors: mct - updated : 10-10-2017
HGNC name lactotransferrin
HGNC id 6720
Location 3p21.31      Physical location : 46.477.496 - 46.506.395
Synonym name lactoferrin
Synonym symbol(s) HLF2, GIG12, LF
DNA
TYPE functioning gene
STRUCTURE 28.90 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
FLJ20209 3p21.32 hypothetical protein FLJ20209 ZDHHC3 3p21.32 zinc finger, DHHC domain containing 3 KIAA0116 3p21 Homo sapiens KIAA0116 protein (KIAA0116), mRNA. TNA 3p21.3 tetranectin (plasminogen binding protein) CDCP1 3p24.3-p22.1 tetranectin (plasminogen binding protein) RIS1 3p21.3 tetranectin (plasminogen binding protein) LARS2 3p21.3 leucyl-tRNA synthetase 2, mitochondrial LIMD1 3p21.3 LIM domains containing 1 SACM1L 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) XT3 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) LZTFL1 3p21.3 leucine zipper transcription factor-like 1 CCR9 3p21.3 chemokine (C-C motif) receptor 9 FYCO1 3p21.3 FYVE and coiled-coil domain containing 1 CXCR6 3p21.3 chemokine (C-X-C motif) receptor 6 XCR1 3p21.3-p21.1 chemokine (C motif) receptor 1 LOC391533 3 similar to Vascular endothelial growth factor receptor 1 precursor (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) CCR1 3p21.31 chemokine (C-C motif) receptor 1 CCR3 3p21.31 chemokine (C-C motif) receptor 3 LTF 3p21.31 lactotransferrin TMEM7 3p21.3 transmembrane protein 7 LRRC2 3p21.3 leucine-rich repeat-containing 2 TDGF1 3p21.31 teratocarcinoma-derived growth factor 1 FLJ36525 3p21.31 hypothetical protein LOC259173 TMIE 3p21 hypothetical protein LOC259173 TSP50 3p14-p12 testes-specific protease 50 TESSP5 3p21.31 testis serine protease 5 LOC391534 3 hypothetical gene supported by AK128390 TESSP2 3p21.31 testis serine protease 2 MYL3 3p21.3 myosin, light polypeptide 3, alkali; ventricular, skeletal, slow PTHR1 3p21.3 parathyroid hormone receptor 1 MGC23918 3p21.31 hypothetical protein MGC23918 KIAA0540 3p21.31 KIAA0540 protein LOC391535 3 similar to p75-like apoptosis-inducing death domain protein PLAIDD HYPB 3p21.2-q22.2 similar to p75-like apoptosis-inducing death domain protein PLAIDD MRP63P3 3p21.31 mitochondrial ribosomal protein 63 pseudogene 3 KIF9 3p21.31 kinesin family member 9 KIAA0795 3p21.31 kinesin family member 9 PTPN23 3p21.3 protein tyrosine phosphatase, non-receptor type 23 SCAP 3p24.3-p22.1 protein tyrosine phosphatase, non-receptor type 23 FLJ20211 3p21.31 hypothetical protein FLJ20211 CSPG5 3p21.3 chondroitin sulfate proteoglycan 5 (neuroglycan C) SMARCC1 3p23-p21 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 DHX30 3p31.31 DEAH (Asp-Glu-Ala-His) box polypeptide 30 MAP4 3p21.3 microtubule-associated protein 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 2390 80 710 - 1997 9122171
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 salivary gland   highly
Lymphoid/Immunespleen   moderately
Nervousbrain   lowly
Reproductivefemale systembreastmammary gland highly Homo sapiens
 male systemprostate  highly
Respiratoryrespiratory tracttrachea  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil Homo sapiens
cell lineage
cell lines
fluid/secretion
  • blood
  • present in milk and a variety of secretions derived from glandular epithelium cells, present at high concentrations
  • at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two peptidase S60 domains
  • conjugated GlycoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Ltf (62.39 pc)
    homolog to murine Ltf (71.06 pc)
    Homologene
    FAMILY
  • transferrin family of iron-binding proteins.
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secondary granules
    basic FUNCTION
  • iron binding transport proteins which can bind two atoms of ferric iron in association with the binding of an anion, usually bicarbonate
  • playing a role in transcription of IL1B and regulating transcription of genes containing lactoferrin binding sites
  • having antimicrobial activity which depends on the extracellular cation concentration
  • upregulating KDR expression
  • stimulating VEGFA-mediated endothelial cell proliferation and migration
  • important protein component of the innate immune system that is broadly distributed within the body fluids
  • major defense protein of innate immunity, and a novel maturation factor for dendritic cells
  • contributes to the activation of both the innate and adaptive immune responses by promoting the recruitment of leukocytes and activation of dendritic cells
  • having the ability to function as a negative regulator of granulocyte migration
  • possible role for its oligomerization in different biological activities
  • acting both as an iron-binding protein and inflammatory modulator
  • induces moderate activation of TLR4-mediated innate immunity through its carbohydrate chains
  • iron-binding protein present in mammalian secretions, playing important roles in cancer prevention by inducing apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text iron
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL1B
  • LTF binds IGBP1 and promotes the acceleration of cellular apoptosis
  • LTF increases the catalytic activity of CTSG at physiological concentration, with its highest enhancing capacity under acidic (pH 5.0) conditions, and broadens the substrate selectivity of CTSG
  • LTF-mediated enhancement of CTSG activity might promote innate immunity during acute inflammation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the brain of patients with Alzheimer disease
    Susceptibility to dental caries
    Variant & Polymorphism other A/G (exon 2, Lys/Arg) polymorphism associated with susceptibility to dental caries
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS