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FLASH GENE
Symbol CCRL2 contributors: mct - updated : 21-10-2013
HGNC name chemokine (C-C motif) receptor-like 2
HGNC id 1612
Location 3p21.31      Physical location : 46.448.720 - 46.451.013
Synonym name
  • chemokine receptor X
  • chemokine receptor CCR11
  • putative MCP-1 chemokine receptor
  • chemokine receptor on activated macrophages A or B
  • Synonym symbol(s) HCR, CKRX, CRAM-A, CRAM-B, CCR6, CCR11, MGC116710
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.29 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D3S3582 - CCRL2 - D3S3560 - D3S1581 - D3S3648 - D3S1578 - D3S1588 - cen
    Authors GeneMap (98)
    regionally located located in a region where the chemokine receptor gene are clustered
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1612 41 356 - 1998 9473515
    CRAM-A
    2 - 1745 39.5 344 - 1998 9473515
    CRAM-B
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Nervousnerve    
    Skin/Tegumentskin     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermis   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    Skin/Tegumentepidermal dendritic cell Homo sapiens
    cell lineage primary neutrophils, primary monocytes
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven transmembrane segments (7TM) receptor
    HOMOLOGY
    intraspecies homolog to CCR1
    Homologene
    FAMILY G protein coupled receptor family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • functional receptor that may be involved in the pathogenesis of rheumatoid arthritis
  • link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1
  • nonredundant role of CCRL2 in lung dendritic cells trafficking and potential role for this receptor in the control of excessive airway inflammatory responses
  • G protein-coupled receptor which plays a key role in lung dendritic cell trafficking to peripheral lymph nodes
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • chemerin (RARRES2) is a natural nonsignaling protein ligand for CCRL2
  • chemokine CCL19 is a specific ligand for CCRL2 (CCL19 is known to be critically involved in lymphocyte and dendritic cell trafficking, and CCL19-binding competition by CCRL2 might be involved in modulating these processes)
  • chemokine CCL5 and CCL19 are reported to bind to CCRL2
  • chemerin, a ligand for CMKLR1, is a ligand for CCRL2 (CCRL2 binds chemerin and increases local chemerin concentration to efficiently present it to CMKLR1 on nearby cells, providing a link between CCRL2 and CMKLR1)
  • RARRES2 is a protein ligand for the G protein-coupled receptor CMKLR1 and also binds to two atypical heptahelical receptors, CCRL2 and GPR1
  • cell & other
    REGULATION
    Other upregulated on neutrophil activation and during monocyte to macrophage differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    on synovial neutrophils of rheumatoid arthritis patients
    tumoral     --over  
    in glioma promotes cell migration and invasion
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • CCRL2(-/-) mice showed normal recruitment of circulating DC into the lung, but a defective trafficking of antigen-loaded lung dendritic cells to mediastinal lymph nodes