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FLASH GENE
Symbol FYCO1 contributors: mct - updated : 09-01-2013
HGNC name FYVE and coiled-coil domain containing 1
HGNC id 14673
Corresponding disease
ARCC4 congenital cataract, autosomal recessive 4
Location 3p21.31      Physical location : 45.959.395 - 46.037.307
Synonym name zinc finger FYVE domain-containing protein 7
Synonym symbol(s) FLJ13335, ZFYVE7, MGC126517, MGC126519, RUFY3
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene, opposite orientation
text including STRL33, within the fourteenth intron of the FYCO1 gene, with an antiparallel transcription orientation.
STRUCTURE 77.93 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D3S3582 - LARS2 - D3S2354 - LIMD1 - SACM1L - SLC6A20 - LZTFL1 - CCR9 - CXCR6 - FYCO1 - XCR1 - NRBF2P - FLI1P - CCR1 - CCR3 - UQCRC2P - CCR5 - CCR2 - CCRL2 - LTF - D3S32 - TMEM7 - LRRC2L - LUZPP1 - TDGF1 - cen
Authors Kiss (02)
Physical map
KIAA1143 3p21.32 KIAA1143 protein KNSL7 3p21.33 kinesin-like 7 MGC29956 3p21.32 hypothetical protein MGC29956 LOC391532 3 similar to peptidyl-Pro cis trans isomerase TGM4 3p22-p21.3 transglutaminase 4 (prostate) FLJ20209 3p21.32 hypothetical protein FLJ20209 ZDHHC3 3p21.32 zinc finger, DHHC domain containing 3 KIAA0116 3p21 Homo sapiens KIAA0116 protein (KIAA0116), mRNA. TNA 3p21.3 tetranectin (plasminogen binding protein) CDCP1 3p24.3-p22.1 tetranectin (plasminogen binding protein) RIS1 3p21.3 tetranectin (plasminogen binding protein) LARS2 3p21.3 leucyl-tRNA synthetase 2, mitochondrial LIMD1 3p21.3 LIM domains containing 1 SACM1L 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) XT3 3p21.3 SAC1 suppressor of actin mutations 1-like (yeast) LZTFL1 3p21.3 leucine zipper transcription factor-like 1 CCR9 3p21.3 chemokine (C-C motif) receptor 9 FYCO1 3p21.3 FYVE and coiled-coil domain containing 1 CXCR6 3p21.3 chemokine (C-X-C motif) receptor 6 XCR1 3p21.3-p21.1 chemokine (C motif) receptor 1 LOC391533 3 similar to Vascular endothelial growth factor receptor 1 precursor (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1) CCR1 3p21.31 chemokine (C-C motif) receptor 1 CCR3 3p21.31 chemokine (C-C motif) receptor 3 LTF 3p21.31 lactotransferrin TMEM7 3p21.3 transmembrane protein 7 LRRC2 3p21.3 leucine-rich repeat-containing 2 TDGF1 3p21.31 teratocarcinoma-derived growth factor 1 FLJ36525 3p21.31 hypothetical protein LOC259173 TMIE 3p21 hypothetical protein LOC259173 TSP50 3p14-p12 testes-specific protease 50 TESSP5 3p21.31 testis serine protease 5 LOC391534 3 hypothetical gene supported by AK128390 TESSP2 3p21.31 testis serine protease 2 MYL3 3p21.3 myosin, light polypeptide 3, alkali; ventricular, skeletal, slow PTHR1 3p21.3 parathyroid hormone receptor 1 MGC23918 3p21.31 hypothetical protein MGC23918 KIAA0540 3p21.31 KIAA0540 protein LOC391535 3 similar to p75-like apoptosis-inducing death domain protein PLAIDD HYPB 3p21.2-q22.2 similar to p75-like apoptosis-inducing death domain protein PLAIDD MRP63P3 3p21.31 mitochondrial ribosomal protein 63 pseudogene 3
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 8518 - 1478 - 2010 20100911
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart   highly
Endocrineparathyroid   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RUN domain
  • a C terminal FYVE domain with two coiled-coid domain in-between
  • HOMOLOGY
    Homologene
    FAMILY
  • ezrin/radixin/moesin family
  • PI(3)P-binding protein family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • colocalize to microtubules and found adjacent to Golgi, but primarily colocalize to autophagosomes
  • basic FUNCTION
  • promotes microtubule (MT) plus end-directed transport of autophagic vesicles
  • functions as an adapter linking autophagosomes to microtubule plus end-directed molecular motors
  • associated with the exterior of autophagosomes and mediating microtubule plus-end-directed vesicle transport
  • involved in lens development and transparency
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to both MAP1LC3A, PtdIns(3)P and RAB7A, and contains a domain responsible for microtubule plus end-dependent transport
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCC4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS