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FLASH GENE
Symbol FYCO1 contributors: mct - updated : 09-01-2013
HGNC name FYVE and coiled-coil domain containing 1
HGNC id 14673
Corresponding disease
ARCC4 congenital cataract, autosomal recessive 4
Location 3p21.31      Physical location : 45.959.395 - 46.037.307
Synonym name zinc finger FYVE domain-containing protein 7
Synonym symbol(s) FLJ13335, ZFYVE7, MGC126517, MGC126519, RUFY3
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene, opposite orientation
text including STRL33, within the fourteenth intron of the FYCO1 gene, with an antiparallel transcription orientation.
STRUCTURE 77.93 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D3S3582 - LARS2 - D3S2354 - LIMD1 - SACM1L - SLC6A20 - LZTFL1 - CCR9 - CXCR6 - FYCO1 - XCR1 - NRBF2P - FLI1P - CCR1 - CCR3 - UQCRC2P - CCR5 - CCR2 - CCRL2 - LTF - D3S32 - TMEM7 - LRRC2L - LUZPP1 - TDGF1 - cen
Authors Kiss (02)
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 8518 - 1478 - 2010 20100911
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart   highly
Endocrineparathyroid   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RUN domain
  • a C terminal FYVE domain with two coiled-coid domain in-between
  • HOMOLOGY
    Homologene
    FAMILY
  • ezrin/radixin/moesin family
  • PI(3)P-binding protein family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • colocalize to microtubules and found adjacent to Golgi, but primarily colocalize to autophagosomes
  • basic FUNCTION
  • promotes microtubule (MT) plus end-directed transport of autophagic vesicles
  • functions as an adapter linking autophagosomes to microtubule plus end-directed molecular motors
  • associated with the exterior of autophagosomes and mediating microtubule plus-end-directed vesicle transport
  • involved in lens development and transparency
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to both MAP1LC3A, PtdIns(3)P and RAB7A, and contains a domain responsible for microtubule plus end-dependent transport
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCC4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS