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FLASH GENE
Symbol SACM1L contributors: mct - updated : 01-06-2011
HGNC name SAC1 suppressor of actin mutations 1-like (yeast)
HGNC id 17059
Location 3p21.3      Physical location : 45.730.753 - 45.786.900
Synonym name
  • suppressor of actin 1
  • phosphatidylinositide phosphatase SAC1
    • Synonym symbol(s) KIAA0851, SAC1, DKFZp686A0231
    EC.number 3.1.3.-
    DNA
    TYPE functioning gene
    STRUCTURE 56.15 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3707 67 587 - 2000 10887188
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • integral membrane protein of the endoplasmic reticulum and the Golgi complex
    • basic FUNCTION
  • possibility that the enzymatic function of SACM1L provides a switch for accessibility of the COPI interaction motif
  • direct roles for MAPK14 and SACM1L in transmitting growth signals to the secretory machinery
  • in quiescent cells stimulated by mitogens, rapidly shuttles back to the endoplasmic reticulum (ER), thus releasing the brake on Golgi secretion
  • executes an essential household function in mammals that involves organization of both Golgi membranes and mitotic spindles and both enzymatic activity and endoplasmic reticulum localization are important SACM1L functional properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • members of the coatomer I (COPI) complex as interaction partners of SACM1L
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS