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FLASH GENE
Symbol SLC16A2 contributors: mct - updated : 24-03-2010
HGNC name solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
HGNC id 10923
Corresponding disease
AHDS Allan-Herndon-Dudley syndrome
MCT8D monocarboxylate transporter 8 deficiency
Location Xq13.2      Physical location : 73.641.084 - 73.753.752
Synonym name
  • solute carrier family 16 (monocarboxylic acid transporters), member 2
  • X-linked PEST-containing transporter
  • solute carrier family 16 (monocarboxylic acid transporters), member 2 (putative transporter)
  • Synonym symbol(s) DXS128E, MCT7, XPCT, DXS128, MCT8
    DNA
    TYPE functioning gene
    STRUCTURE 112.67 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - DXS559 - OGT - DXS131 - DXS162 - RPS4X - CITED1 - DXS227 - NAP1L2 - CDX4 - CHIC1 - XIST - JPX - FTX - ZCCHC13 - SLC16A2 - DXS441 - DXS171 - DXS347 - DXS325 - DXS356 - qter
    Physical map
    RPS4X Xq13.1 ribosomal protein S4, X-linked CITED1 Xq13.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 HDAC8 Xq13 histone deacetylase 8 PHKA1 Xq13.1 phosphorylase kinase, alpha 1 (muscle) DMRTC1 Xq13.1 DMRT-like family C1 MGC34827 Xq13.1 hypothetical protein MGC34827 LOC340529 Xq13.1 hypothetical protein LOC340529 LOC392491 X similar to hypothetical protein LOC340529 LOC392492 X similar to Nap1l2 NAP1L2 Xq13.2 nucleosome assembly protein 1-like 2 LOC392493 X hypothetical gene supported by BC000882; NM_014765 LOC392494 X similar to YWHAZ protein CDX4 Xq13.2 caudal type homeo box transcription factor 4 LOC139201 Xq13.1 mitogen-activated protein kinase kinase 4 pseudogene LOC389872 X similar to cysteine-rich hydrophobic 1 (CHIC1) protein LOC389873 X similar to selenophosphate synthetase 1 XIST Xq13.2 X (inactive)-specific transcript LOC260337 Xq13.1 zinc finger protein Np97 pseudogene LOC139932 Xq13.1 similar to DEAD-box protein 3 (Helicase-like protein 2) (HLP2) (DEAD-box, X isoform) MKRNP1 Xq13 makorin, ring finger protein, pseudogene 1 LOC347359 Xq13.1 similar to BMP-2 inducible protein kinase (BIKe) (HRIHFB2017) LOC392496 X similar to Rab coupling protein; Rab-interacting recycling protein; Rab effector protein; rab11-family interacting protein 1 LOC389874 X cellular nucleic acid binding protein-like LOC392497 X similar to 40S ribosomal protein S6 (Phosphoprotein NP33) LOC286493 Xq13.2 similar to Interferon-inducible, double stranded RNA dependent inhibitor, protein-kinase LOC392498 X similar to 40S ribosomal protein S7 (S8) SLC16A2 Xq13.2 solute carrier family 16 (monocarboxylic acid transporters), member 2 (putative transporter) PABPCP3 Xq13 poly(A) binding protein, cytoplasmic, pseudogene 3 RNF12 Xq13-q21 ring finger protein 12 KIAA2022 Xq13.2 KIAA2022 protein ABCB7 Xq13 ATP-binding cassette, sub-family B (MDR/TAP), member 7 MGC23937 Xq13.2 hypothetical protein MGC23937 similar to CG4798 LOC389875 X similar to telomeric repeat binding factor 1 isoform 2; Telomeric repeat binding factor 1; telomeric repeat binding protein 1 ZDHHC15 Xq13.1 zinc finger, DHHC domain containing 15 BRAF2 Xq13.2 similar to v-raf murine sarcoma viral oncogene homolog B1 pseudogene LOC286495 Xq13.2 similar to Tetratricopeptide repeat protein 3 (TPR repeat protein D) HCA3 Xq13.2 hepatocellular carcinoma-associated protein HCA3 MGC874 Xq13.2 hypothetical protein MGC874 LDHBP Xq13.2-q13.3 lactate dehydrogenase B pseudogene KIAA1587 Xq13.2 hepatocellular carcinoma-associated protein HCA1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4396 - 613 - 2008 18668440
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrain   highly Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
     brainforebraincerebral cortex   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve hydrophobic transmembrane spanning segments
  • a large cytoplasmic loop between TM6 and TM7 and
  • a N terminal PEST domain
    • HOMOLOGY
    interspecies homolog to murine Slc16a2
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating movement of lactate and pyruvate across membranes
  • involved in the transport of triiodothyronine into neurons, very active and specific thyroid hormone transporter
  • with SLC16A10, facilitate iodothyronine uptake as well as efflux
  • may play an important role in the transport of thyroid hormone in the brain, which is essential for the crucial action of the hormone during brain development
  • may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transporter
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • proton linked
    • protein
  • PTTG1IP binds and alters the subcellular localization of SLC16A2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCT8D , AHDS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS