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FLASH GENE
Symbol OGT contributors: mct/pgu - updated : 21-11-2016
HGNC name O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
HGNC id 8127
Location Xq13.1      Physical location : 70.752.911 - 70.795.747
Synonym name
  • O-linked GlcNAc transferase
  • O-GlcNAc transferase subunit p110
  • UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
  • uridinediphospho-N-acetylpeptide:polypeptide beta-N-acetylglucosaminyltransferase
  • Synonym symbol(s) HRNT1, O-GLCNAC, FLJ23071, MGC22921
    EC.number 2.4.1.94/2.4.1.255
    DNA
    TYPE functioning gene
    STRUCTURE 42.84 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - DXS983 - GJB1 - IL2RG - RPS4X - PGK1 PGK1 ,OGT - ATP7A - DXS1002 - DXS995 - qter
    Authors Gene Map (98)
    Physical map
    SLC7A3 Xq12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 LOC392488 X similar to Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) SNX12 Xq12-q13.1 sorting nexin 12 MLLT7 Xq13.1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 LOC158830 Xq13.1 similar to Ab2-183 IL2RG Xq12-q13.1 interleukin 2 receptor, gamma (severe combined immunodeficiency) TNRC11 Xq13 trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit) NLGN3 Xq13.1 neuroligin 3 GJB1 Xq13.1 gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) ZNF261 Xq13.1 zinc finger protein 261 NONO Xq13.1 non-POU domain containing, octamer-binding ITGB1BP2 Xq12.1-q13 integrin beta 1 binding protein (melusin) 2 LOC392489 X similar to ras homolog gene family, member G (rho G); RhoG TAF1 Xq13.1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa ING2 Xq12 inhibitor of growth family, member 2 OGT Xq13 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) ACRC Xq13.1 acidic repeat containing CXCR3 Xq13 chemokine (C-X-C motif) receptor 3 LOC158825 Xq13.1 hypothetical LOC158825 LOC389868 X LOC389868 LOC389869 X LOC389869 LOC389870 X LOC389870 LOC389871 X LOC389871 LOC286539 Xq13.1 similar to 40S ribosomal protein S26 KIAA2001 Xq13.1 KIAA2001 protein LOC340527 Xq13.1 similar to Nance-Horan syndrome (congenital cataracts and dental anomalies); NHS gene LOC392490 X similar to Translationally controlled tumor protein (TCTP) (p23) (Histamine-releasing factor) (HRF) PIN4 Xq13 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) FLJ20105 Xq13.1 hypothetical protein FLJ20105 RPS4X Xq13.1 ribosomal protein S4, X-linked CITED1 Xq13.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 HDAC8 Xq13 histone deacetylase 8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 splicing 5497 116.8 1046 - 1997 9083068
  • isoform 1
  • 22 splicing 5467 115.6 1036 - 1997 9083068
  • lacking a segment within the coding region compared to variant 1
  • translation in frame compared to variant 1
  • isoform 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   moderately
     thymus   highly
    Nervousbrain   highlyHomo sapiens
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region consisting of a series of tetratricopeptide repeat (TPR) units19, 20 and a multidomain catalytic region
  • thirteen tetratricopeptide (TPR) repeats (twelve full domain and one truncated) interacting with the coiled-coil domains of ALS2CR3 and OIP106
  • a possible phosphatidylinositol (3,4,5)-trisphosphate (PIP3) binding domain involved in membrane recruitment in response to insulin signalling
  • conjugated PhosphoP , Other
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to rattus Ogt (99.4 pc)
    homolog to murine Ogt (99.6 pc)
    Homologene
    FAMILY
  • O-GlcNAc transferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text expressed in the nucleocytoplasmic compartments
    basic FUNCTION
  • involved in addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine
  • OGT modification participates in the regulation of CAMK4 activation and function, possibly coordinating nutritional signals with the immune and nervous systems (
  • essential (in mouse) for embryonic stem cell viability
  • regulates mitotic chromatin dynamics
  • catalyzes O-GlcNAc) addition to numerous cellular proteins including transcription and nuclear pore complexes and plays a key role in cellular signaling
  • catalyses the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine (UDP-GlcNAc) to serines and threonines of cytoplasmic, nuclear and mitochondrial proteins
  • function of OGT in hormone signaling
  • modification of OGT is involved in many important cellular processes
  • essential role of O-GlcNAcylation during early development
  • TET2-dependent O-GlcNAcylation of chromatinand the double epigenetic modifications on both DNA and histones by TET2 and OGT coordinate together for the regulation of gene transcription
  • catalyzes serine and threonine glycosylation
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling signal transduction
    protein glycosylation
    a component
  • heterotrimer composed of two 110 kDa and one 78kDa (proteolytic product of the former) subunits
  • large proportion of the signaling enzyme OGT is complexed with HCFC1 and this interaction is essential for HCFC1 cleavage
  • BAP1 forms a core complex with HCFC1 and OGT that can differentially recruit additional histone-modifying enzymes to regulate gene expression and thereby preserve normal hematopoiesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with THAP1, THAP3 and thus involved in cell proliferation
  • HCFC1 is required for stabilizing OGT in the nucleus (interactions of OGT with multiple HCFC1 domains may indicate that OGT has several functions in association with HCFC1)
  • TAB1 is modified through OGT on a single site, Ser395 (this modification is induced by IL1 and osmotic stress, known inducers of the MAP3K7 signalling cascade)
  • associates with ligand-bound glucocorticoid receptor in a multi-protein repression complex
  • interacts with the tetratricopeptide repeat binding site of HSP90AA1
  • TET2 and TET3 associate with OGT, an enzyme that by itself catalyses the addition of O-GlcNAc onto serine and threonine residues (O-GlcNAcylation)
  • OGT associates with TET2 at transcription start sites
  • TET1 and TET2 as stable partners of OGT in the nucleus of ESCs
  • link between TET1 and OGT activities in regulating CpG island methylation
  • POU2F1 integrates metabolic and stress signals via OGT modification to regulate target gene activity
  • OGT-modification of CAMK2A is a novel signalling event in pathways that may contribute critically to cardiac and neuronal pathophysiology in diabetes and other diseases
  • OGT is not only a major TET3-interacting protein but also regulates TET3 subcellular localization and enzymatic activity
  • mediates O-GlcNAcylation of the SNARE protein SNAP29 and regulates autophagy in a nutrient-dependent manner
  • OGT modifies and regulates an essential epigenetic tool, RNF2, which may contribute to embryonic stem cells (hESC) pluripotency maintenance and differentiation
  • distinct OGT-binding sites in HCFC1 promote proteolysis
  • KMT2E protein stability is cooperatively regulated by O-GlcNAc transferase (OGT) and ubiquitin-specific protease 7 (USP7)
  • cell & other
    REGULATION
    Other acetylated
    HSP90AA1 is involved in the regulation of OGT and O-GlcNAc modification
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    homeostasis of OGT cycling is critical to, and its dysregulation is involved in, neurodegenerative diseases
    constitutional     --over  
    implicated in major diseases, such as diabetes and its complications and cardiovascular and neurodegenerative diseases
    constitutional     --over  
    results in an increase in abnormal chromosomal bridge formation
    constitutional     --over  
    increased the inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1) and reduced the phosphorylation of CDK1 target proteins
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    cycling provides a new target for investigation of these disease mechanisms and for drug development
    ANIMAL & CELL MODELS