Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RPS4X contributors: mct - updated : 11-03-2020
HGNC name ribosomal protein S4, X-linked
HGNC id 10424
Location Xq13.1      Physical location : 71.492.453 - 71.497.141
Synonym name
  • cell cycle gene 2
  • 40S ribosomal protein S4, X isoform
  • single copy abundant mRNA protein
    • Synonym symbol(s) CCG2, DXS306, SCAR, SCR10, FLJ40595, RPS4, S4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE escaping inactivation
    text escaping inactivation
    STRUCTURE 5.21 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - DXS1275 - ED1 - MLLT7 - DXS983 - DXS8107 - DXS8052 - [IL2RG ,GJB1 ,TAF1 ] - PHKA1 - CDX4 - DXS1005E ,XIST ,RPSAP14 - DXS8037 ,DXS8092 ,DXS1221 ,DXS7025E ,DXS1103E ,SLC16A2 ,DXS8060 ,DXS8066 - ATRX ATRX - DXS6980E - qter
    Authors Mumm (98), LaFrenière (93)
    Text [RPS4X ]
    RNA
    TRANSCRIPTS type messenger
    text X-linked isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1474 29 263 - 1994 8139551
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyoblast Homo sapiens
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KOW (Kyprides, Ouzounis, Woese) motif
    • HOMOLOGY
    intraspecies paralog to RPS4Y
    Homologene
    FAMILY
  • ribosomal protein S4e family
    • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • 40S ribosomal protein S4 involved in protein biosynthesis, development, cell proliferation, regulation of cell cycle
  • involved in cellular translation and proliferation
  • higher RPS4X expression in both myoblasts and myotubes from women, together with lower methylation levels in the promoter
  • escapes X inactivation
    • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    associated with a lower risk of death and later disease progression in serous epithelial ovarian cancer
    constitutional     --over  
    RPS4X exhibited the highest expression in XXY (
    tumoral     --low  
    is associated with poor disease-specific and recurrence-free survival in bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • RPS4X is an independent prognostic factor in patients with serous epithelial ovarian cancer
    • Therapy target
    ANIMAL & CELL MODELS