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FLASH GENE
Symbol CITED1 contributors: mct/npt - updated : 08-07-2008
HGNC name Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
HGNC id 1986
Location Xq13.1      Physical location : 71.521.489 - 71.527.037
Synonym name melanocyte-specific gene 1
Synonym symbol(s) MSG1
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 5.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - ED1 - IL2RG ,TAF1 - DXS131 - RPS4X ,PHKA1 ,DXS227 ,CITED1 - XIST ,DXS128 - PGK1 PGK1 - qter
Authors Fenner (98)
Physical map
GJB1 Xq13.1 gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) ZNF261 Xq13.1 zinc finger protein 261 NONO Xq13.1 non-POU domain containing, octamer-binding ITGB1BP2 Xq12.1-q13 integrin beta 1 binding protein (melusin) 2 LOC392489 X similar to ras homolog gene family, member G (rho G); RhoG TAF1 Xq13.1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa ING2 Xq12 inhibitor of growth family, member 2 OGT Xq13 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) ACRC Xq13.1 acidic repeat containing CXCR3 Xq13 chemokine (C-X-C motif) receptor 3 LOC158825 Xq13.1 hypothetical LOC158825 LOC389868 X LOC389868 LOC389869 X LOC389869 LOC389870 X LOC389870 LOC389871 X LOC389871 LOC286539 Xq13.1 similar to 40S ribosomal protein S26 KIAA2001 Xq13.1 KIAA2001 protein LOC340527 Xq13.1 similar to Nance-Horan syndrome (congenital cataracts and dental anomalies); NHS gene LOC392490 X similar to Translationally controlled tumor protein (TCTP) (p23) (Histamine-releasing factor) (HRF) PIN4 Xq13 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) FLJ20105 Xq13.1 hypothetical protein FLJ20105 RPS4X Xq13.1 ribosomal protein S4, X-linked CITED1 Xq13.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 HDAC8 Xq13 histone deacetylase 8 PHKA1 Xq13.1 phosphorylase kinase, alpha 1 (muscle) DMRTC1 Xq13.1 DMRT-like family C1 MGC34827 Xq13.1 hypothetical protein MGC34827 LOC340529 Xq13.1 hypothetical protein LOC340529 LOC392491 X similar to hypothetical protein LOC340529 LOC392492 X similar to Nap1l2 NAP1L2 Xq13.2 nucleosome assembly protein 1-like 2 LOC392493 X hypothetical gene supported by BC000882; NM_014765 LOC392494 X similar to YWHAZ protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1203 - 193 - Lovvorn (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
Reproductivemale systemtestis   
Skin/Tegumentskin    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte
cell lineage
cell lines pigmented melanoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear protein with a serine /threonine-rich region
  • a glutamic-aspartic (ED) rich C terminal domain with transactivating activity
  • HOMOLOGY
    interspecies homolog to murine Cited1
    Homologene
    FAMILY CITED family of cofactors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional activator dependent on transforming growth factor beta signaling pathway and interaction with SMAD4
  • functioning as a cell cycle-dependent transcriptional cofactor whose activity is regulated by phosphorylation
  • involved in regulating a wide variety of CBP/p300-dependent transcriptional responses
  • CELLULAR PROCESS cell life
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text epidermal development and maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MADH4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the condensed metanephric mesenchyme could play a role in Wilms tumor initiation and pathogenesis
    tumoral     --over  
    in papillary thyroid carcinoma (PTC), pigmented melanoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker of primitive blastema in Wilms tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS