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FLASH GENE
Symbol NAP1L2 contributors: npt/ - updated : 17-06-2005
HGNC name nucleosome assembly protein 1-like 2
HGNC id 7638
Location Xq13.2      Physical location : 72.432.154 - 72.434.684
Synonym name
  • brain specific gene BPX
  • brain-specific protein, X-linked
  • Synonym symbol(s) BPX, MGC26243
    DNA
    TYPE functioning gene
    STRUCTURE 2.53 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    text structure one cpG island and numerous sites for the transcription factors (PBX1)
    MAPPING cloned Y linked   status provisional
    Physical map
    OGT Xq13 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) ACRC Xq13.1 acidic repeat containing CXCR3 Xq13 chemokine (C-X-C motif) receptor 3 LOC158825 Xq13.1 hypothetical LOC158825 LOC389868 X LOC389868 LOC389869 X LOC389869 LOC389870 X LOC389870 LOC389871 X LOC389871 LOC286539 Xq13.1 similar to 40S ribosomal protein S26 KIAA2001 Xq13.1 KIAA2001 protein LOC340527 Xq13.1 similar to Nance-Horan syndrome (congenital cataracts and dental anomalies); NHS gene LOC392490 X similar to Translationally controlled tumor protein (TCTP) (p23) (Histamine-releasing factor) (HRF) PIN4 Xq13 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) FLJ20105 Xq13.1 hypothetical protein FLJ20105 RPS4X Xq13.1 ribosomal protein S4, X-linked CITED1 Xq13.1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 HDAC8 Xq13 histone deacetylase 8 PHKA1 Xq13.1 phosphorylase kinase, alpha 1 (muscle) DMRTC1 Xq13.1 DMRT-like family C1 MGC34827 Xq13.1 hypothetical protein MGC34827 LOC340529 Xq13.1 hypothetical protein LOC340529 LOC392491 X similar to hypothetical protein LOC340529 LOC392492 X similar to Nap1l2 NAP1L2 Xq13.2 nucleosome assembly protein 1-like 2 LOC392493 X hypothetical gene supported by BC000882; NM_014765 LOC392494 X similar to YWHAZ protein CDX4 Xq13.2 caudal type homeo box transcription factor 4 LOC139201 Xq13.1 mitogen-activated protein kinase kinase 4 pseudogene LOC389872 X similar to cysteine-rich hydrophobic 1 (CHIC1) protein LOC389873 X similar to selenophosphate synthetase 1 XIST Xq13.2 X (inactive)-specific transcript LOC260337 Xq13.1 zinc finger protein Np97 pseudogene LOC139932 Xq13.1 similar to DEAD-box protein 3 (Helicase-like protein 2) (HLP2) (DEAD-box, X isoform) MKRNP1 Xq13 makorin, ring finger protein, pseudogene 1 LOC347359 Xq13.1 similar to BMP-2 inducible protein kinase (BIKe) (HRIHFB2017) LOC392496 X similar to Rab coupling protein; Rab-interacting recycling protein; Rab effector protein; rab11-family interacting protein 1 LOC389874 X cellular nucleic acid binding protein-like LOC392497 X similar to 40S ribosomal protein S6 (Phosphoprotein NP33) LOC286493 Xq13.2 similar to Interferon-inducible, double stranded RNA dependent inhibitor, protein-kinase LOC392498 X similar to 40S ribosomal protein S7 (S8) SLC16A2 Xq13.2 solute carrier family 16 (monocarboxylic acid transporters), member 2 (putative transporter) PABPCP3 Xq13 poly(A) binding protein, cytoplasmic, pseudogene 3 RNF12 Xq13-q21 ring finger protein 12
    regionally located centromeric to XIST
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2559 - 460 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Bpx
    intraspecies paralog to NAP1Ls
    Homologene
    FAMILY
  • nucleosome assembly protein 1 (NAP1) family
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulating neural cell proliferation with chromatin
  • play overlapping roles in transport and deposition of histone H2A-H2B or H2A variants-H2B dimers on chromatin and nonoverlapping roles in nucleosome disassembly (Okuwaki 2010)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to chromatin
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to neural tube defects
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS