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FLASH GENE
Symbol MAOA contributors: mct - updated : 14-09-2011
HGNC name monoamine oxidase A
HGNC id 6833
Corresponding disease
MAOA/BD MAOA/B deletion syndrome
MRIB mental retardation with impulsive behavior
Location Xp11.23      Physical location : 43.515.408 - 43.606.067
EC.number 1.4.3.4
DNA
TYPE functioning gene
STRUCTURE 90.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map pter - DXS993 - DXS1201 - DXS228 - DXS77 - DXS7 - MAOA - MAOB - NDP - RRM2P3 - DXS742 - UBE1 - DXS1264 - DXS1055 - DXS1003 - DXS1146 - DXS1266 - ARAF - SYN1 - TIMP1 - PFC - (DXS426 ,ELK1 ) - DXS1367 - ZNF81 - ZNF21 - DXS1267 - TBC1D25 - DXS722 - GATA1 - DXS226 - DXS1126 - DXS1240 - DXS1011E - (TFE3 ,SYP ) - DXS255 - DXS146 - OATL2 - cen
Authors Consensus, Willard (94)
Physical map
MKRN4 Xp21.1 makorin, ring finger protein, 4 LOC392447 X similar to 60S ribosomal protein L32 LOC286444 Xp11.4 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC392448 X similar to Chloride intracellular channel protein 4 (mc3s5/mtCLIC) USP9X Xp11.4 ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila) DDX3X Xp11.3-p11.23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked NYX Xp11.4 nyctalopin CASK Xp11.4 calcium/calmodulin-dependent serine protein kinase (MAGUK family) LOC158781 Xp11.4 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene GPR34 Xp11.4-p11.3 G protein-coupled receptor 34 GPR82 Xp11.4 G protein-coupled receptor 82 I-4 Xp11.4-Xp11.3 type 1 protein phosphatase inhibitor LOC139334 Xp11.4 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 LOC392449 X similar to Nanog homeobox; homeobox transcription factor Nanog LOC389847 X similar to Amine oxidase [flavin-containing] A (Monoamine oxidase) (MAO-A) MAOA Xp11.23 monoamine oxidase A MAOB Xp11.23 monoamine oxidase B NDP Xp11.4 Norrie disease (pseudoglioma) LOC286398 Xp11.4 similar to RNA-binding region containing protein 2 (Hepatocellular carcinoma protein 1) (Splicing factor HCC1) FLJ22843 Xp11.4 hypothetical protein FLJ22843 RRM2P3 Xp21-p11 ribonucleotide reductase M2 polypeptide pseudogene 3 LOC139339 Xp11.4 similar to ubinuclein 1 LOC392450 X similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) MGC51029 Xp11.4 hypothetical protein MGC51029 LOC392451 X similar to hypothetical protein LOC389848 X similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) UTX Xp11.3-p11.23 ubiquitously transcribed tetratricopeptide repeat gene, X chromosome DUSP21 Xp11.4-p11.23 dual specificity phosphatase 21 FLJ14103  hypothetical protein FLJ14103 LOC139061 Xp11.3 similar to plasmolipin LOC347333 Xp11.3 similar to tau tubulin kinase 2; tau-tubulin kinase LOC392452 X similar to RIKEN cDNA 5230400G24 LOC392453 X similar to arginine/serine-rich splicing factor 6; splicing factor, arginine/serine-rich, 55 kDa; pre-mRNA splicing factor SRP55 LOC139060 Xp11.3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC392454 X similar to Proliferating cell nuclear antigen (PCNA) (Cyclin) PCNAP Xp11 proliferating cell nuclear antigen pseudogene LOC392455 X similar to beta actin LOC392456 X similar to beta catenin-like 1; nuclear associated protein; chromosome 20 open reading frame 33 LOC389849 X similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) FLJ20344 Xp11.3 hypothetical protein FLJ20344 RNU6P1 Xp11.3 RNA, U6 small nuclear pseudogene 1 LOC392457 X similar to Antigen KI-67 CHST7 Xp11.23 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Reproductivefemale systemplacenta  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • flavin containing amine oxidase domain
  • anchored to the outer mitochondrial membrane via C-terminal helical tails
  • mono polymer homomer , heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Maob
    intraspecies paralog to MAOB
    Homologene
    FAMILY flavin monoamine oxidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • degrading amine neurotransmitters (such as dopamine, norepinephrin and serotonin)
  • having important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
  • MAOA, SLC6A2, SLC6A3 may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus
  • novel roles for MAOA, MAOB and serotonin in the regulation of intermediate progenitor cells proliferation in the developing brain
  • MAOA and MAOB are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide
  • MAOA, and MAOB are dimeric in their membrane-bound forms
  • MAOA and MAOB are mitochondrial-bound proteins, catalyzing the oxidative deamination of monoamine neurotransmitters as well as xenobiotic amines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism amine , hormone
    signaling neurotransmission
    metabolism of various biogenic amine hormones
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • FAD
  • protein
  • interacting with CDCA7L (inhibits the MAOA promoter and enzymatic activities)
  • SLC6A2
  • PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRIB , MAOA/BD
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in female panic desorders
    constitutional     --low  
    significantly lower platelet MAOA activity in children with hyperactive, inattentive, and combined subtype of ADHD than in control children
    Susceptibility
  • to anorexia nervosa and to Parkinson disease
  • to delinquent behavior in adolescence and young adulthood
  • Variant & Polymorphism other rare 2 repeat of the 30-bp VNTR2, associated with delinquent behavior in adolescence and young adulthood
    Candidate gene for obesity in dupXp11p21 patients
    Marker
    Therapy target
    ANIMAL & CELL MODELS